Results 111 to 120 of about 46,505 (316)

Optimization using surrogate models and partially converged computational fluid dynamics simulations [PDF]

, 2006
Efficient methods for global aerodynamic optimization using computational fluid dynamics simulations should aim to reduce both the time taken to evaluate design concepts and the number of evaluations needed for optimization.
Alexander I.J. Forrester, Andy J. Keane, Keane, A.J., Forrester, A.I.J., Bressloff, N.W., Neil W. Bressloff   +5 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Structural Analysis of a Dragonfly Wing

, 2010
Dragonfly wings are highly corrugated, which increases the stiffness and strength of the wing significantly, and results in a lightweight structure with good aerodynamic performance.
Jongerius, S.R., S. R. Jongerius, D. Lentink, Lentink, D.   +3 more
core   +1 more source

Computational aerodynamics and design [PDF]

, 1982
The availability of supercomputers and the ingenuity of computational aerodynamics in design, and prospects for continued advancement are assessed.
openaire   +1 more source

Aerodynamic Design of a Solar Road Vehicle

International Journal of Automotive Technology, 2018
Solar road vehicles have very specific design requirements. This makes their aerodynamic characteristics quite different from classic sedan vehicles. In the present study, the computational model of a typical solar road vehicle is developed to investigate its aerodynamic forces and flow characteristics.
Majdandžić, Ljubomir, Buljić, Dalibor, Buljac, Andrija, Kozmar, Hrvoje   +3 more
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Simulation of wake vortex effects for UAVs in close formation flight [PDF]

, 2009
This paper addresses the development of multiple UAV deployment simulation models that include representative aerodynamic cross-coupling effects. Applications may include simulations of autonomous aerial refuelling and formation flying scenarios.
Whidborne, James F., D. Saban, Cooke, Alastair K., A. K. Cooke, J. F. Whidborne, Saban, Deborah   +5 more
core   +1 more source

Research on wind tunnel test of low-speed characteristics optimization in Kink area of transport aircraft wings

Hangkong gongcheng jinzhan
For conventionally laid out civil transport aircraft in low-speed condition and high lift configurations, the advance of the stall angle of attack causes the aircraft's approach speed to be too high, it is necessary to optimize the low-speed ...
YAN Wei, XU Huiwen, LI Jinye, ZHANG Ziyang, ZHANG Meihong, ZHAO Keliang, JIAO Renshan, WANG Fei, YAN Wencheng, ZENG Weiping   +9 more
doaj   +1 more source