Results 111 to 120 of about 163,941 (314)
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Numerical Aerodynamic Simulation [PDF]
An overview of historical and current numerical aerodynamic simulation (NAS) is given. The capabilities and goals of the Numerical Aerodynamic Simulation Facility are outlined.
core +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Aerodynamic validation of a SCAR design [PDF]
Wind tunnel test of the McDonnell Douglas Supersonic Cruise Aircraft, designed for a cruise Mach number of 2.2, was conducted in the NASA Ames Unitary Plan Wind Tunnels.
Roensch, R. L.
core +1 more source
Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells
FEBS Open Bio, EarlyView.UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca +6 more
wiley +1 more source
Research progress on aerodynamic stealth design technology of aircraft
Hangkong gongcheng jinzhanAerodynamic stealth design is a key technology for aircraft to realize efficient combat in high-risk environments，and it has been a hot technology researched by aviation powers for a long time.
ZHAO Ke +5 more
doaj +1 more source
Full potential methods for analysis/design of complex aerospace configurations [PDF]
The steady form of the full potential equation, in conservative form, is employed to analyze and design a wide variety of complex aerodynamic shapes. The nonlinear method is based on the theory of characteristic signal propagation coupled with novel flux
Bonner, Ellwood +2 more
core +1 more source
Short-duration, transonic flow, variable-porosity test section [PDF]
, 1970 Short-duration test facility obtains extremely high Reynolds number flows in subsonic, transonic, and supersonic speed ranges, and aids in solving Reynolds number-dependent aerodynamic and thermodynamic problems in design and testing of large, high speed
Davis, J. W., Hill, O. E.
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Hypersonic structures: An aerodynamicist's perspective, or one man's dream is another man's nightmare [PDF]
The relationship between hypersonic aerodynamic and structural design is reviewed. The evolution of the hypersonic vehicle design is presented.
Hunt, J. L. +2 more
core +1 more source