Results 121 to 130 of about 46,505 (316)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Design & modelling of a composite rudderless aeroelastic fin structure [PDF]
, 2010 This thesis presents the study of a gapless and rudderless aeroelastic fin (GRAF) to enhance the directional stability and controllability of an aircraft. The GRAF concept was proposed and developed in the wake of previous research, targeted to improve
Trapani, Matteo
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2013 The creation of an integrated rotorcraft conceptual and preliminary design framework at DLR involved the development of geometry and fuselage aerodynamics modules at the Institute of Aerodynamics and Flow Technology.
Kunze, Philipp
core
Conceptual design and optimization methodology for box wing aircraft [PDF]
, 2012 A conceptual design optimization methodology was developed for a medium range box wing aircraft. A baseline conventional cantilever wing aircraft designed for the same mis- sion and payload was also optimized alongside a baseline box wing aircraft.
Jemitola, Paul Olugbeji
core
, 2011 PhDThe study of rotor blade aerodynamic performances of wind tur- bine has been presented in this thesis. This study was focused on aero- dynamic effects changed by blade surface distribution as well as grid solution along the airfoil.
Emrah Kulunk, Horikiri, Kana
core +1 more source
Adjoint-based RCS surface sensitivity calculation for very large electrical size object
Defence TechnologyThe primary concern in stealth aircraft design is the very large electrical size objects. However, the computational and storage requirements of these objects present significant obstacles for current high-fidelity design methods, particularly when ...
Jun Deng +5 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Applied Ocean ResearchWing-in-ground effect (WIG) craft represents a class of high-performance ship, utilizing ground effect to achieve ultra-low-height flight with an exceptional lift-to-drag ratio.
Yiheng Wang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source