Results 141 to 150 of about 12,489,898 (339)

Aerodynamic Design and Performance Analysis of a Large-Scale Composite Blade for Wind Turbines

Applied Sciences
In this study, we determined an aerodynamic configuration to design structures applying composites for large-scale horizontal-axis wind turbine blades. A new aerodynamic and structural design method for large wind turbine blades is presented.
Semyoung Lim, Sungjin Ahn, Hyunbum Park
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hypersonic structures: An aerodynamicist's perspective, or one man's dream is another man's nightmare [PDF]

The relationship between hypersonic aerodynamic and structural design is reviewed. The evolution of the hypersonic vehicle design is presented.
Hunt, J. L., Jackson, L. R., Watts, J. D.   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Full potential methods for analysis/design of complex aerospace configurations [PDF]

The steady form of the full potential equation, in conservative form, is employed to analyze and design a wide variety of complex aerodynamic shapes. The nonlinear method is based on the theory of characteristic signal propagation coupled with novel flux
Bonner, Ellwood, Shankar, Vijaya, Szema, Kuo-Yen   +2 more
core   +1 more source

Control of large thermal distortions in a cryogenic wind tunnel [PDF]

, 1983
The National Transonic Facility (NTF) is a research wind tunnel capable of operation at temperatures down to 89K (160 R) and pressures up to 900,000 Pa (9 atmospheres) to achieve Reynolds numbers approaching 120,000,000.
Gustafson, J. C.
core   +1 more source

Application of a PCA-DBN-based surrogate model to robust aerodynamic design optimization

Chinese Journal of Aeronautics, 2020
Jun Tao, Gang Sun, Liqiang Guo, Xinyu Wang   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Airfoil Design Optimization of Blended Wing Body for Various Aerodynamic and Stealth Stations

Aerospace
The airfoil is the foundation of an aircraft, and its characteristics have a significant impact on those of the aircraft. Conventional airfoil design mainly focuses on improving aerodynamic performance, while flying wing airfoil designs should also ...
Wei Zhang, Lin Zhou, Ke Zhao, Ruibin Zhang, Zhenghong Gao, Bowen Shu   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source