Results 91 to 100 of about 3,513,025 (239)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Report of the Energy Efficiency Board. 2014.
, 2015 Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Report of the Energy Efficiency Board. 2012.
, 2013 Annual; Began with 2010.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core
Energy Efficiency Board 2019 programs and operations report.
, 2020 Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core
NUMERICAL INVESTIGATION OF TWO ELEMENT CAMBER MORPHING AIRFOIL IN LOW REYNOLDS NUMBER FLOWS [PDF]
Journal of Engineering Science and Technology, 2017 Aerodynamic performance of a two-element camber morphing airfoil was investigated at low Reynolds number using the transient SST model in ANSYS FLUENT 14.0 and eN method in XFLR5. The two-element camber morphing concept was employed to morph the baseline
RAJESH SENTHIL KUMAR T. +3 more
doaj
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
AerospaceAerodynamic/stealth optimization is a key issue during the design of a stealth UAV. Balancing the weight of different incident angles of the RCS and combining stealth characteristics with aerodynamic characteristics are hotspots of aerodynamic/stealth ...
Chengen Yuan +3 more
doaj +1 more source