Results 71 to 80 of about 3,513,025 (239)

Optimization Design of Blades Based on Multi-Objective Particle Swarm Optimization Algorithm

Journal of Marine Science and Engineering
Among renewable energy sources derived from the ocean, wind power has developed rapidly. This article proposes an optimization algorithm framework that integrates two objectives: aerodynamic shape optimization and structural optimization.
Zihao Li, Wei Wang, Yonghe Xie, Detang Li   +3 more
doaj   +1 more source

Aerodynamic efficiency enhancement for asymmetric profiles

MATEC Web of Conferences, 2018
This paper presents a solution for enhancement of aerodynamic efficiency for asymmetric airfoils. In order to increase the lift and reduce the drag forces for a blade segment, a groove was created on its surface.
Bostan Viorel, Guţu Marin, Odainâi Valeriu   +2 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Improving aerodynamic performance of intermodal trains through optimisation of loading plans

Archives of Transport
This paper addresses the improvement of energy efficiency in intermodal freight trains by reducing aerodynamic drag through optimisation of container arrangement on railcars.
Karol Nehring, Łukasz Kiszkowiak
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

On the Use of Wing Adaptation and Formation for Improved Aerodynamic Efficiency

, 2005
There is a continuous effort to improve the performance and efficiency of today's aircraft, and the reduction of aircraft drag has been the primary focus of many aerodynamicists.
King, Rachel Marie
core  

Numerical and experimental study on aerodynamic design for the rear wing of an electric sports car

Kongqi donglixue xuebao
The rear wing is a core component determining the aerodynamic downforce of sports cars. In the design of electric sports cars, its aerodynamic development faces a fundamental contradiction: enhancing downforce to improve handling stability while ...
Kai Liu, Qiuli Luo, Junyao Wang, Qingyu Wang, Fengli Zhang, Wenjiang Wang, Rongrong Zhang   +6 more
doaj   +1 more source

Numerical investigation on the aerodynamic efficiency of bio-inspired corrugated and cambered airfoils in ground effect. [PDF]

Sci Rep, 2022
Abdizadeh GR, Farokhinejad M, Ghasemloo S.   +2 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source