Results 61 to 70 of about 5,447,507 (295)

The Effect of Airfoil Geometry Variation on the Efficiency of a Small Wind Turbine

Technologies
This study analyzes the impact of geometric variations induced by the manufacturing process on the aerodynamic efficiency of an airfoil used in the design of a 3 kW wind turbine blade.
José Rafael Dorrego Portela, Orlando Lastres Danguillecourt, Víctor Iván Moreno Oliva, Eduardo Torres Moreno, Cristofer Aguilar Jimenez, Liliana Hechavarría Difur, Quetzalcoatl Hernandez-Escobedo, Jesus Alejandro Franco   +7 more
doaj   +1 more source

Implementation of Three-Dimensional Inverse Design and Its Application to Improve the Compressor Performance

Energies, 2020
The implementation of a three-dimensional viscous inverse design used for an axial compressor is introduced in this paper. The derivation process of the inverse design algorithm is also described in detail. Moreover, an improved blade update method and a
Yu Duan, Qun Zheng, Bin Jiang, Aqiang Lin, Wenfeng Zhao   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Integrated Aerodynamic–Propulsion Optimization for Gas-Powered Fan VTOL Systems via CFD and Genetic Algorithms

Aerospace
Vertical takeoff and landing (VTOL) aircraft must balance the conflicting demands of hover and cruise performance. To address the lack of integrated design methodologies in the existing literature, a unified design-optimization framework is presented ...
Mohammad Javad Pour Razzaghi, Guoping Huang, Yuanzhao Zhu   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The aerodynamics and efficiency of wind pollination in grasses

Functional Ecology, 2010
Summary1. Under natural selection for sexual success, the reproductive organs of plants should evolve to become highly effective pollen receptors. Among wind‐pollinated plants, larger reproductive structures appear counter‐adapted to accumulate pollen by impaction on their windward surfaces, because airborne particles are less able to penetrate the ...
Cresswell, James, Krick, J, Patrick, MA, Lahoubi, M   +3 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Aerodynamic Analysis of Hovering Flapping Wing Using Multi-Plane Method and Quasi-Steady Blade Element Theory

Applied Sciences
In the design of flapping-wing micro-size air vehicles capable of hovering, wings serve as the primary source of hovering power, making the analysis of aerodynamics and aerodynamic efficiency crucial.
Ruiqi Ye, Ziming Liu, Jin Cui, Chenyang Wang, Yirong Wu   +4 more
doaj   +1 more source