Results 61 to 70 of about 3,513,025 (239)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Lifting-Line Predictions for the Ideal Twist Effectiveness of Spanwise Continuous and Discrete Control Surfaces

Applied Sciences
Modern materials and manufacturing technologies have allowed the construction of morphing wings that are able to continuously vary certain airfoil parameters such as twist, camber, or control surface deflection as a function of span. This work presents a
Zachary S. Montgomery, Douglas F. Hunsaker, James J. Joo   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Impacts of tires on aerodynamic performance of a Formula Student electric vehicle: A high-resolution three-dimensional Reynolds-averaged Navier–Stokes study [PDF]

AIP Advances
Optimizing aerodynamic performance is paramount for enhancing the energy efficiency of electric vehicles. Reducing aerodynamic drag directly extends driving range and lowers battery consumption, making aerodynamics a fundamental element in modern ...
Junbiao He, Tao Yang, Yicheng Chi, Peng Zhang   +3 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Error estimation and adaptive mesh refinement for aerodynamic flows [PDF]

, 2010
We consider the adjoint-based error estimation and goal-oriented mesh refinement for single and multiple aerodynamic force coefficients as well as residual-based mesh refinement applied to various three-dimensional laminar and turbulent aerodynamic test ...
Ralf Hartmann, Tobias Leicht, Prill, Florian, Florian Prill, Leicht, Tobias, Held, Joachim, Joachim Held, Hartmann, Ralf   +7 more
core   +1 more source

A Mathematical Model to Analyze the Static Stability of Hybrid (Aero- Hydrodynamically Supported) Vehicles. [PDF]

, 2008
Among the new concepts developed for high speed marine vehicles over the last two decades, the "aerodynamic alleviation" approach consists in using an aerodynamic surface to "alleviate" the weight sustained by the hydrodynamic lift.
Patel, Minoo H., Trarieux, Florent, Collu, Maurizio   +2 more
core   +3 more sources

Aerodynamic Optimization of an Over-the-Wing-Nacelle-Mount Configuration

Modelling and Simulation in Engineering, 2011
An over-the-wing-nacelle-mount airplane configuration is known to prevent the noise propagation from jet engines toward ground. However, the configuration is assumed to have low aerodynamic efficiency due to the aerodynamic interference effect between a ...
Daisuke Sasaki, Kazuhiro Nakahashi
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source