Results 41 to 50 of about 5,447,507 (295)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Thermal and aerodynamic efficiency of a stationary switching regenerative heat exchanger
IOP Conference Series: Earth and Environment, 2019 The article is devoted to comparison of thermal and aerodynamic efficiency of two configurations of the regenerative nozzle used in the regenerative heat exchanger for room ventilation.
N. Monarkin +6 more
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Wind Turbine Enhancement via Active Flow Control Implementation
Applied SciencesThe present research enhances the efficiency of an airfoil section from the DTU-10MW Horizontal Axis Wind Turbine (HAWT) via Active Flow Control (AFC) implementation and when using synthetic jets (SJ).
Marc Lahoz +3 more
doaj +1 more source
International Journal of Rotating Machinery, 2017 Centrifugal turbine which has less land occupation, simple structure, and high aerodynamic efficiency is suitable to be used as small to medium size steam turbines or waste heat recovery plant.
Hui Li, Dian-Gui Huang
doaj +1 more source
Flow Control in Wings and Discovery of Novel Approaches via Deep Reinforcement Learning
Fluids, 2022 In this review, we summarize existing trends of flow control used to improve the aerodynamic efficiency of wings. We first discuss active methods to control turbulence, starting with flat-plate geometries and building towards the more complicated flow ...
Ricardo Vinuesa +3 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Drvna Industrija, 2016 This paper introduces a numerical methodology based on a 3D turbulent flow computation developed to assess the aerodynamic performances of lumber drying kilns.
Bogdan Bedelean +2 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source