Results 41 to 50 of about 3,513,025 (239)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
PERFORMANCE OF 3D PRINTED CONVENTIONAL AND TOROIDAL PROPELLER FOR SMALL MULTIROTOR DRONES
Journal of Industrial Design and Engineering Graphics, 2023 This paper presents a study on the design, fabrication, and performance evaluation of a quadcopter with toroidal propellers manufactured using 3D printing technology.
Gabriel ION, Ionel SIMION
doaj
AIP Advances, 2020 Numerical simulations of the unsteady aerodynamic characteristics of the flapping wing composite motion are performed. To avoid negative grid sizes arising with the use of a dynamic grid and leading to divergences in the simulation and to errors in the ...
Lun Li +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Aerodynamic investigations of ventilated brake discs. [PDF]
, 2005 The heat dissipation and performance of a ventilated brake disc strongly depends on the aerodynamic characteristics of the flow through the rotor passages.
MacManus, David G., Parish, D.
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The Effect of Airfoil Geometry Variation on the Efficiency of a Small Wind Turbine
TechnologiesThis study analyzes the impact of geometric variations induced by the manufacturing process on the aerodynamic efficiency of an airfoil used in the design of a 3 kW wind turbine blade.
José Rafael Dorrego Portela +7 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
AerospaceVertical takeoff and landing (VTOL) aircraft must balance the conflicting demands of hover and cruise performance. To address the lack of integrated design methodologies in the existing literature, a unified design-optimization framework is presented ...
Mohammad Javad Pour Razzaghi +2 more
doaj +1 more source