Results 51 to 60 of about 3,513,025 (239)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Aerodynamic Characteristics of Ducted Propulsion Fan Using Secondary Air Intake

Eng
Ducted propulsion fans are widely recognized for their ability to enhance aerodynamic efficiency and operational safety by utilizing a surrounding shroud to contain the flow and mitigate blade tip losses.
Thai-Son Vu, Binh-Nguyen Nguyen, Hoang-Quan Chu, Gia-Diem Pham, Cong Truong Dinh   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Report of the Energy Efficiency Board. 2013.

, 2014
Annual; Began with 2010; ceased with 2011.; At head of title: Connecticut Energy Efficiency ...
Connecticut. Energy Efficiency Board.
core   +1 more source

Parametric Analysis of Trapezoidal Segmentation for Wing Planform Efficiency

Aerospace
This paper introduces a refined criterion for evaluating and optimizing the aerodynamic efficiency of compound planform wings, specifically those whose half span is formed by multiple trapezoidal segments.
Dmytro Tiniakov, Krittisak Limtrakul
doaj   +1 more source

Aerodynamic Optimization Design of a Multistage Centrifugal Steam Turbine and Its Off-Design Performance Analysis

International Journal of Rotating Machinery, 2017
Centrifugal turbine which has less land occupation, simple structure, and high aerodynamic efficiency is suitable to be used as small to medium size steam turbines or waste heat recovery plant.
Hui Li, Dian-Gui Huang
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Implementation of Three-Dimensional Inverse Design and Its Application to Improve the Compressor Performance

Energies, 2020
The implementation of a three-dimensional viscous inverse design used for an axial compressor is introduced in this paper. The derivation process of the inverse design algorithm is also described in detail. Moreover, an improved blade update method and a
Yu Duan, Qun Zheng, Bin Jiang, Aqiang Lin, Wenfeng Zhao   +4 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

National Action Plan for Energy Efficiency, Chapter 6: Energy Efficiency Program Best Practices

, 2006
Chapter from the National Action Plan for Energy Efficiency documenting key findings from energy efficiency programs that have been successfully operating for many ...
National Action Plan for Energy Efficiency (U.S.)
core