Results 51 to 60 of about 12,726 (261)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Integrated Aerodynamic–Propulsion Optimization for Gas-Powered Fan VTOL Systems via CFD and Genetic Algorithms

Aerospace
Vertical takeoff and landing (VTOL) aircraft must balance the conflicting demands of hover and cruise performance. To address the lack of integrated design methodologies in the existing literature, a unified design-optimization framework is presented ...
Mohammad Javad Pour Razzaghi, Guoping Huang, Yuanzhao Zhu   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Aerodynamic Characteristics of Ducted Propulsion Fan Using Secondary Air Intake

Eng
Ducted propulsion fans are widely recognized for their ability to enhance aerodynamic efficiency and operational safety by utilizing a surrounding shroud to contain the flow and mitigate blade tip losses.
Thai-Son Vu, Binh-Nguyen Nguyen, Hoang-Quan Chu, Gia-Diem Pham, Cong Truong Dinh   +4 more
doaj   +1 more source

The aerodynamics and efficiency of wind pollination in grasses

Functional Ecology, 2010
Summary1. Under natural selection for sexual success, the reproductive organs of plants should evolve to become highly effective pollen receptors. Among wind‐pollinated plants, larger reproductive structures appear counter‐adapted to accumulate pollen by impaction on their windward surfaces, because airborne particles are less able to penetrate the ...
Cresswell, James, Krick, J, Patrick, MA, Lahoubi, M   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Parametric Analysis of Trapezoidal Segmentation for Wing Planform Efficiency

Aerospace
This paper introduces a refined criterion for evaluating and optimizing the aerodynamic efficiency of compound planform wings, specifically those whose half span is formed by multiple trapezoidal segments.
Dmytro Tiniakov, Krittisak Limtrakul
doaj   +1 more source

Implementation of Three-Dimensional Inverse Design and Its Application to Improve the Compressor Performance

Energies, 2020
The implementation of a three-dimensional viscous inverse design used for an axial compressor is introduced in this paper. The derivation process of the inverse design algorithm is also described in detail. Moreover, an improved blade update method and a
Yu Duan, Qun Zheng, Bin Jiang, Aqiang Lin, Wenfeng Zhao   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source