Results 81 to 90 of about 5,447,507 (295)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Improving aerodynamic performance of intermodal trains through optimisation of loading plans

Archives of Transport
This paper addresses the improvement of energy efficiency in intermodal freight trains by reducing aerodynamic drag through optimisation of container arrangement on railcars.
Karol Nehring, Łukasz Kiszkowiak
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Numerical and experimental study on aerodynamic design for the rear wing of an electric sports car

Kongqi donglixue xuebao
The rear wing is a core component determining the aerodynamic downforce of sports cars. In the design of electric sports cars, its aerodynamic development faces a fundamental contradiction: enhancing downforce to improve handling stability while ...
Kai Liu, Qiuli Luo, Junyao Wang, Qingyu Wang, Fengli Zhang, Wenjiang Wang, Rongrong Zhang   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Design of a wind turbine rotor for maximum aerodynamic efficiency

Wind Energy, 2008
AbstractThe design of a three‐bladed wind turbine rotor is described, where the main focus has been highest possible mechanical power coefficient, CP, at a single operational condition. Structural, as well as off‐design, issues are not considered, leading to a purely theoretical design for investigating maximum aerodynamic efficiency.The rotor is ...
Johansen, Jeppe, Madsen, Helge Aa., Gaunaa, Mac, Bak, Christian, Sørensen, Niels   +4 more
openaire   +2 more sources

Time-Varying Wing-Twist Improves Aerodynamic Efficiency of Forward Flight in Butterflies

PLoS ONE, 2013
Insect wings can undergo significant chordwise (camber) as well as spanwise (twist) deformation during flapping flight but the effect of these deformations is not well understood.
Lingxiao Zheng, T. Hedrick, R. Mittal
semanticscholar   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

INVESTIGATION AND MODIFICATION OF AERODYNAMIC CHARACTERISTICS OF SUPERSONIC AIRCRAFT

Journal of Engineering, 2010
Increasing the aerodynamic efficiency and enhancing the supermaneuverability for the selected supersonic aircraft (F-16A) is presented. Aerodynamic characteristics, surface pressure distribution and maximum lift are are estimated for the baseline ...
Jafar M. Hassan, Laith K. Abbass, Laith W. Ismail   +2 more
doaj   +1 more source