Results 91 to 100 of about 90,246 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Impact of Aerodynamic Interactions on Aeroelastic Stability of Wing-Propeller Systems

Applied Sciences
This paper presents initial findings from aeroelastic studies conducted on a wing-propeller model, aimed at evaluating the impact of aerodynamic interactions on wing flutter mechanisms and overall aeroelastic performance.
Nils Böhnisch, Carsten Braun, Pier Marzocca, Vincenzo Muscarello   +3 more
doaj   +1 more source

Coupling analysis of transient aerodynamic and dynamic response of cars in overtaking under crosswinds

Engineering Applications of Computational Fluid Mechanics, 2020
The aerodynamic performance and dynamic response of two cars in overtaking maneuver under crosswind were investigated using a multi-car two-way coupling method.
Chuqi Su, Zhen Hu, Qianwen Zhang, Xiaohong Yuan, Chengcai Zhang, Yiping Wang   +5 more
doaj   +1 more source

Analysis of wing-body interaction flutter for a preliminary space shuttle design [PDF]

Subsonic flutter analyses for a preliminary space shuttle design were performed to determine the effect of wing-body aerodynamic interaction on the vehicle flutter speed.
Chipman, R. R., Shyprykevich, P.
core   +1 more source

The influence of blade curvature and helical blade twist on the performance of a vertical-axis wind turbine [PDF]

, 2010
Accurate aerodynamic modeling of vertical-axis wind turbines poses a significant challenge, but is essential if the performance of such turbines is to be predicted reliably.
Brown, R.E., Fletcher, Timothy M., Scheurich, Frank   +2 more
core  

Lip Trill: Aerodynamic, Acoustic, and Laryngeal Interactions

Journal of Voice
The lip trill (an oscillatory semioccluded vocal tract (SOVT) exercise) is commonly used by singers and speakers to improve voice production skills. The specific objective of this study was to investigate the relationships between aerodynamic and acoustic signals during lip trills.One trained female singer performed lip trill with and without voicing ...
Sophia Dove, Ronald C. Scherer, Edrie Means Weekly   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The calculation of rotor/fuselage interaction for two-dimensional bodies [PDF]

Unsteady rotor wake interactions with the empennage, tail boom, and other aerodynamic surfaces have a significant influence on the aerodynamic performance of the helicopter, ride quality, and vibration.
Stremel, Paul M.
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Simulation of self-induced unsteady motion in the near wake of a Joukowski airfoil [PDF]

The unsteady Navier-Stokes analysis is shown to be capable of analyzing the massively separated, persistently unsteady flow in the post-stall regime of a Joukowski airfoil for an angle of attack as high as 53 degrees.
Ghia, K. N., Ghia, U., Osswald, G. A.
core   +1 more source