Results 81 to 90 of about 90,246 (309)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A theoretical study of serrated leading edges in aerofoil and vortical gust interaction noise
Advances in Aerodynamics, 2019 Serrated leading edges are one of the most promising passive aerodynamic control methods for the reduction of aerofoil–turbulence interaction noise.
Xun Huang
doaj +1 more source
A numerical study on aerodynamic resonance in transonic separated flow [PDF]
, 2009 An ongoing numerical investigation of unsteady shock/boundary layer interaction on a 2-d supercritical airfoil in transonic flow is presented. Initially, the finitevolume URANS solver DLR-TAU is used to simulate self-sustained periodic shock oscillations
Nitzsche, Jens
core
Nonlinear aeroelastic modeling via conformal mapping and vortex method for a flat-plate airfoil in arbitrary motion [PDF]
, 2016 A nonlinear aerodynamic modeling based on conformal mapping is presented to obtain semi-analytical formulas for the unsteady aerodynamic force and pitching moment on a flat-plate airfoil in arbitrary motion.
Mastroddi, Franco +2 more
core +1 more source
AERODYNAMICS OF JETS INTERACTING WITH A FLAT SURFACE
Izvestiya. Ferrous Metallurgy, 2019 In this paper, the development features of a single free jet of hightemperature nitrogen interacting with a flat surface were studied. Calculation of the heat exchange process during heating by the attacking jets is very difficult to implement analytically due to complexity of the gas-dynamic processes occurring both in a single jet and in a system of ...
I. A. Pribytkov, S. I. Kondrashenko
openaire +2 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Effects of jets, wakes, and vortices on lifting surfaces [PDF]
The interaction of jets, wakes, and vortices on lifting bodies represents a broad spectrum of aerodynamic flow phenomena.
Margason, R. J.
core +1 more source
Computational study of a complex three-dimensional shock boundary-layer interaction [PDF]
, 2015 Shock boundary–layer interactions occur in many high-speed aerodynamic flows and they can have a notable impact on design considerations due to the aerodynamic and heat transfer effects.
Katzenberg, Joshua, MacManus, David G.
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source