Results 81 to 90 of about 1,044,517 (354)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The DELTA MONSTER: An RPV designed to investigate the aerodynamics of a delta wing platform [PDF]
The mission requirements for the performance of aerodynamic tests on a delta wind planform posed some problems, these include aerodynamic interference; structural support; data acquisition and transmission instrumentation; aircraft stability and control;
Connolly, Kristen +8 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Measurement of Mutual Interference Sound of Columnar Objects in Air Flow
MATEC Web of Conferences, 2018 When a columnar object is put in a flow, Karman vortex is formed, and aerodynamic noise is generated. It is known that when multiple columnar objects are put in a flow, the flow state becomes complex.
Hamada Shohji, Yokoi Yoshifumi
doaj +1 more source
Special opportunities in helicopter aerodynamics [PDF]
Aerodynamic research relating to modern helicopters includes the study of three dimensional, unsteady, nonlinear flow fields. A selective review is made of some of the phenomenon that hamper the development of satisfactory engineering prediction ...
Mccroskey, W. J.
core +1 more source
Status of advanced turboprop technology [PDF]
, 1978 Research is reviewed in the following areas: turboprop powered transport aircraft; wind tunnel aerodynamic and acoustics tests of model propellers; turboprop maintenance; and wind tunnel tests on airframe-turboprop interactions.
Dugan, J. F. +2 more
core +1 more source
Aerodynamic noise from rigid trailing edges with finite porous extensions
, 2017 This paper investigates the effects of finite flat porous extensions to semi-infinite impermeable flat plates in an attempt to control trailing-edge noise through bio-inspired adaptations.
Ayton, L. J., Kisil, A. V.
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Advanced Transonic Aerodynamic Technology [PDF]
Supercritical airfoils and their applications to wings for various types of aircraft are studied. The various wings discussed were designed for a subsonic jet transport with increased speed, a variable sweep fighter with greater transonic maneuverability,
Whitcomb, R. T.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source