Results 101 to 110 of about 67,904 (291)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Advances in Aerodynamic Shape Optimization [PDF]

, 2005
The accumulated experience of the last decade suggests that most existing aircraft which cruise at transonic speeds are amenable to a drag reduction of the order of 3 to 5 percent, or an increase in the drag rise Mach number of at least .02. These improvements can be achieved by very small shape modifications, which are too subtle to allow their ...
openaire   +1 more source

Integrated aerodynamic/dynamic optimization of helicopter rotor blades [PDF]

An integrated aerodynamic/dynamic optimization procedure is used to minimize blade weight and 4 per rev vertical hub shear for a rotor blade in forward flight.
Chattopadhyay, Aditi, Riley, Michael F., Walsh, Joanne L.   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Propeller Aerodynamic Design and Optimization

, 2023
This research endeavors to illuminate the path toward efficient and optimized propeller design by delving into the realm of aerodynamics. Propellers, as vital mechanical marvels, constitute the core of numerous propulsion systems, spanning from aircraft and marine vessels to wind turbines.
openaire   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Identification of aerodynamic coefficients of a projectile and reconstruction of its trajectory from partial flight data

Computer Assisted Methods in Engineering and Science, 2017
Several optimization techniques are proposed both to identify the aerodynamic coefficients and to reconstruct the trajectory of a fin-stabilized projectile from partial flight data.
Vincent Condaminet, Franck Delvare, Daniel Choï, Hélène Demailly, Christophe Grignon, Settie Heddadj   +5 more
doaj   +1 more source

Quantification of airfoil geometry-induced aerodynamic uncertainties - comparison of approaches

, 2016
Uncertainty quantification in aerodynamic simulations calls for efficient numerical methods since it is computationally expensive, especially for the uncertainties caused by random geometry variations which involve a large number of variables. This paper
Litvinenko, Alexander, Liu, Dishi, Schillings, Claudia, Schulz, Volker   +3 more
core   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Transonic Buffet Suppression by Airfoil Optimization

Aerospace
The main buffet suppression techniques of aircrafts include active and passive flow control, aiming to reduce the impact of the fluctuating loads on the airfoil. These techniques are remedies after the airfoil design. The buffet suppression is not always
Yiming Gong, Chuanqiang Gao, Weiwei Zhang   +2 more
doaj   +1 more source