Results 81 to 90 of about 15,080 (315)

The Aerodynamic Effects of Runback Ice [PDF]

, 2013
The objectives of this PhD were to investigate the aerodynamic performance effects due to runback ice accretion with particular interest on the EASA 45 minute hold case in icing conditions. The sponsors, Airbus and Cranfield University collaboratively
Parmar, Krishan
core  

Optimization design for aerodynamic elements of high speed trains

, 2014
The complex wake flow of high speed trains severely influences the running safety and amenity of the trailing car. In this paper, based on the streamlined shape of CRH380A high speed train, taking the aerodynamic lift force of the trailing car and the ...
孙振旭, 杨国伟, Sun, ZX (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China., 姚拴宝, 郭迪龙, 陈大伟   +5 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Advances in Aerodynamic Shape Optimization [PDF]

, 2005
The accumulated experience of the last decade suggests that most existing aircraft which cruise at transonic speeds are amenable to a drag reduction of the order of 3 to 5 percent, or an increase in the drag rise Mach number of at least .02. These improvements can be achieved by very small shape modifications, which are too subtle to allow their ...
openaire   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Adjoint Optimization for Hyperloop Aerodynamics

Vehicles
This work investigates how the vehicle-to-tube suspension gap governs compressible flow physics and operating margins in Hyperloop-class transport at 10 kPa. To our knowledge, this is the first study to apply adjoint aerodynamic optimization to mitigate gap-induced choking and shock formation in a full pod–tube configuration.
Mohammed Mahdi Abdulla, Seraj Alzhrani, Khalid Juhany, Ibraheem AlQadi   +3 more
openaire   +1 more source

Investigation on Adjoint Based Gradient Computations for Realistic 3d Aero-Optimization

, 2010
A discrete adjoint method for e ciently computing gradients for aerodynamic shape op- timizations is presented. The chain itself involves an unstructured mesh Reynolds-Averaged Navier-Stokes solver, and is suitable for the optimization of complex ...
Brezillon, Joel, Caslav, Ilic, Leicht, Tobias, Widhalm, Markus   +3 more
core  

Surfaces de réponse par krigeage pour l'optimisation de formes aérodynamiques [PDF]

, 2008
Les simulations numériques RANS, utilisées en aérodynamique pour évaluer la performance d'une forme, sont coûteuses en temps de calcul. Comme une optimisation nécessite l'étude de plusieurs dizaines de formes différentes, ce coût limite le champ des ...
Laurenceau, Julien
core