Results 71 to 80 of about 1,911,947 (284)

Stealth Unmanned Aerial Vehicle Penetration Efficiency Optimization Based on Radar Detection Probability Model

Aerospace
Aerodynamic/stealth optimization is a key issue during the design of a stealth UAV. Balancing the weight of different incident angles of the RCS and combining stealth characteristics with aerodynamic characteristics are hotspots of aerodynamic/stealth ...
Chengen Yuan, Dongli Ma, Yuhong Jia, Liang Zhang   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Efficient aerodynamic shape optimization by using unsupervised manifold learning to filter geometric features

Engineering Applications of Computational Fluid Mechanics
Many aerodynamic shape optimization methods often focus on utilizing the end-to-end relationship between design variables and aerodynamic performance to find the optimal design, while overlooking the exploration of geometric knowledge of the shape itself.
Long Ma, Xiao-Jing Wu, Wei-Wei Zhang
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An optimization procedure of shape and position of the aerodynamic device at the rear side of a semi-trailer truck model

Heliyon
The paper outlines the development and optimization of an aerodynamic device for a semi-trailer truck model to reduce aerodynamic drag force. The optimization procedure involves the selection of a basic aerodynamic device shape, using airfoil profiles ...
Stjepan Galamboš, Nebojša Nikolić, Goran Vorotović, Boris Stojić, Jovan Dorić, Dalibor Feher   +5 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Application of Multidisciplinary Design Optimization on Advanced Configuration Aircraft

Journal of Aerospace Technology and Management, 2017
An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on
Yalin Pan, Jun Huang, Feng Li, Chuxiong Yan   +3 more
doaj  

Application of Nontraditional Optimization Techniques for Airfoil Shape Optimization

Modelling and Simulation in Engineering, 2012
The method of optimization algorithms is one of the most important parameters which will strongly influence the fidelity of the solution during an aerodynamic shape optimization problem.
R. Mukesh, K. Lingadurai, U. Selvakumar
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source