Results 61 to 70 of about 5,838 (267)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An optimization procedure of shape and position of the aerodynamic device at the rear side of a semi-trailer truck model

Heliyon
The paper outlines the development and optimization of an aerodynamic device for a semi-trailer truck model to reduce aerodynamic drag force. The optimization procedure involves the selection of a basic aerodynamic device shape, using airfoil profiles ...
Stjepan Galamboš, Nebojša Nikolić, Goran Vorotović, Boris Stojić, Jovan Dorić, Dalibor Feher   +5 more
doaj   +1 more source

Application of Nontraditional Optimization Techniques for Airfoil Shape Optimization

Modelling and Simulation in Engineering, 2012
The method of optimization algorithms is one of the most important parameters which will strongly influence the fidelity of the solution during an aerodynamic shape optimization problem.
R. Mukesh, K. Lingadurai, U. Selvakumar
doaj   +1 more source

Adjoint Optimization for Hyperloop Aerodynamics

Vehicles
This work investigates how the vehicle-to-tube suspension gap governs compressible flow physics and operating margins in Hyperloop-class transport at 10 kPa. To our knowledge, this is the first study to apply adjoint aerodynamic optimization to mitigate gap-induced choking and shock formation in a full pod–tube configuration.
Mohammed Mahdi Abdulla, Seraj Alzhrani, Khalid Juhany, Ibraheem AlQadi   +3 more
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Application of Multidisciplinary Design Optimization on Advanced Configuration Aircraft

Journal of Aerospace Technology and Management, 2017
An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on
Yalin Pan, Jun Huang, Feng Li, Chuxiong Yan   +3 more
doaj  

Geometry Design Optimization of a Wind Turbine Blade Considering Effects on Aerodynamic Performance by Linearization

Energies, 2020
For a wind turbine to extract as much energy as possible from the wind, blade geometry optimization to maximize the aerodynamic performance is important.
Kyoungboo Yang
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source