Results 51 to 60 of about 1,911,947 (284)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Efficient Adaptive Robust Aerodynamic Design Optimization Considering Uncertain Inflow Variations for a Diffusion Airfoil Across All Operating Incidences

Aerospace
The random fluctuations in inlet flow represent a common uncertainty in aero-engine compressors, necessitating the control of its effects through blade optimization design.
Zhengtao Guo, Lei Bao, Chaolong Li, Xianzhong Gao, Wuli Chu   +4 more
doaj   +1 more source

Aircraft Lateral-Directional Aerodynamic Parameter Identification and Solution Method Using Segmented Adaptation of Identification Model and Flight Test Data

Aerospace, 2022
Current aerodynamic parameter identification methods take the consistency between the response of the motion model reconstructed with the identified aerodynamic parameters and flight data as an optimization index. Since there is only one index constraint
Lixin Wang, Rong Zhao, Yi Zhang
doaj   +1 more source

Optimization and Generation in Aerodynamics Inverse Design

CoRR
Aerodynamic inverse design can improve vehicle and aircraft efficiency, but practical design rarely seeks performance alone: vehicle refinement must reduce drag while preserving visual features linked to design language, brand recognition and user perception.
Chen, Huaguan, Lin, Ning, Chen, Luxi, Cen, Jiacheng, Zhang, Rui, Huang, Wenbing, Li, Chongxuan, Sun, Hao   +7 more
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Accelerated Airfoil Optimization via a Geometry-Based Discriminator Within Particle Swarm Optimization

IEEE Access
Particle swarm optimization (PSO) is widely used for aerodynamic shape optimization; however, its practical efficiency is often limited by the high computational cost of aerodynamic evaluations and the frequent generation of geometrically unrealistic ...
Leul Walelign Michael, Abdulazez Abagero, Abera Tullu, Yoseph Mekonnen Abebe, Sunghun Jung   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

An Improved Approach for Reducing the Dimensionality of Wing Aerodynamic Optimization Considering Longitudinal Stability

Aerospace
The wing aerodynamic shape optimization is a typical high-dimensional problem with numerous independent design variables. Researching methods to reduce the dimensionality of optimization from the perspective of aerodynamic characteristics is necessary ...
Boqian Ji, Jun Huang, Xiaoqiang Lu, Yacong Wu, Jingjiang Liu   +4 more
doaj   +1 more source

Fluid-Mechanics-Based Aerodynamic Design of Electric Vehicles [PDF]

MATEC Web of Conferences
As the range requirements for electric vehicles (EVs) continue to increase, reducing air resistance has become a feasible approach for vehicle energy conservation optimization.
Zhang Hancheng
doaj   +1 more source