Results 41 to 50 of about 1,911,947 (284)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Optimization using surrogate models and partially converged computational fluid dynamics simulations [PDF]

, 2006
Efficient methods for global aerodynamic optimization using computational fluid dynamics simulations should aim to reduce both the time taken to evaluate design concepts and the number of evaluations needed for optimization.
Alexander I.J. Forrester, Andy J. Keane, Keane, A.J., Forrester, A.I.J., Bressloff, N.W., Neil W. Bressloff   +5 more
core   +1 more source

Aerodynamic Optimization of a Winglet Design [PDF]

EPJ Web of Conferences, 2013
In the present study, an experimental study is presented for a flow around an isolated wing equipped by a winglet and profiled with Naca 0012. Several cases of winglets were tested according to the angle ß: 0°, 55°, 65°and 75°. For all these cases at a velocity of 20, 30 and 40 meters per second, wind tunnel tests are performed and compared for ...
S. Belferhat, Sidi Mohamed Amine Meftah, Tayeb Yahiaoui, Bachir Imine   +3 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Aerodynamic design optimization using flow feature parameterization

, 2007
Design optimization methods using high-fidelity computational fluid dynamics simulations are becoming increasingly popular in the area of aerodynamic design, sustaining the desire to make these methods more computationally efficient.
Barrett, Thomas Robin
core   +1 more source

Aerodynamic and Stealth Integrated Design of DSI Inlet by Surrogate-Based Multi-Objective Optimization with EHVI Infill Criterion

Xibei Gongye Daxue Xuebao, 2019
To deal with the problem of aerodynamic and stealth integrated optimization of DSI inlet, a multi-objective optimization study on aerodynamic and stealth of the DSI inlet is carry out which based on the deformation of the three-dimensional compression ...

doaj   +1 more source

Machine Learning Assisted Prediction of Airfoil Lift-to-Drag Characteristics for Mars Helicopter

Aerospace, 2023
The aerodynamic properties of rotor systems operating within low Reynolds number flow field conditions are profoundly influenced by their geometric and flight parameters.
Pengyue Zhao, Xifeng Gao, Bo Zhao, Huan Liu, Jianwei Wu, Zongquan Deng   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Wing Design and Adaptive Optimization of a Compound Drone

气体物理
With the growing demand for unmanned transportation, the rise of compound drones is imperative. Aerodynamic optimization design plays a significant role in the development cycle of compound drones.
Wei ZHANG, Meng TAN, Yafeng LIU, Yongbin NIE, Yue LUAN   +4 more
doaj   +1 more source