Results 41 to 50 of about 68,481 (311)
Tiltrotor CFD part II: aerodynamic optimisation of tiltrotor blades [PDF]
, 2017 This paper presents aerodynamic optimisation of tiltrotor blades with high-fidelity computational fluid dynamics. The employed optimisation framework is based on a quasi-Newton method, and the required high-fidelity flow gradients were computed using a
Barakos, G.N. +5 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Wing Design and Adaptive Optimization of a Compound Drone
气体物理With the growing demand for unmanned transportation, the rise of compound drones is imperative. Aerodynamic optimization design plays a significant role in the development cycle of compound drones.
Wei ZHANG +4 more
doaj +1 more source
Multidisciplinary design of a micro-USV for re-entry operations [PDF]
, 2010 Unmanned Space Vehicles (USV) are seen as a test-bed for enabling technologies and as a carrier to deliver and return experiments to and from low-Earth orbit.
Liqiang, Hou +2 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Discrete Adjoint-Based Simultaneous Analysis and Design Approach for Conceptual Aerodynamic Optimization [PDF]
INCAS Bulletin, 2017 In this paper, a simultaneous analysis and design method is derived and applied for a non-linear constrained aerodynamic optimization problem. The method is based on the approach of defining a Lagrange functional based on the objective function and the ...
Oliviu SUGAR-GABOR
doaj +1 more source
Atmosphere, 2022 Corner modifications can reduce wind loads acting on supertall buildings and modify the corresponding flow structures. The present study investigated the aerodynamic shape optimization of the corner recession square cylinders with multiple geometric ...
Zhaoyong Wang +3 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
AerospaceThe random fluctuations in inlet flow represent a common uncertainty in aero-engine compressors, necessitating the control of its effects through blade optimization design.
Zhengtao Guo +4 more
doaj +1 more source
Quantification of airfoil geometry-induced aerodynamic uncertainties - comparison of approaches [PDF]
, 2016 Uncertainty quantification in aerodynamic simulations calls for efficient numerical methods since it is computationally expensive, especially for the uncertainties caused by random geometry variations which involve a large number of variables. This paper
Litvinenko, Alexander +3 more
core +2 more sources