Results 81 to 90 of about 67,904 (291)
On simple aerodynamic sensitivity derivatives for use in interdisciplinary optimization [PDF]
Low-aspect-ratio and piston aerodynamic theories are reviewed as to their use in developing aerodynamic sensitivity derivatives for use in multidisciplinary optimization applications.
Doggett, Robert V., Jr.
core +1 more source
Aerodynamic Optimization of High-Speed Trains Nose using a Genetic Algorithm and Artificial Neural Network [PDF]
, 2011 An aerodynamic optimization of the train aerodynamic characteristics in term of front wind action sensitivity is carried out in this paper. In particular, a genetic algorithm (GA) is used to perform a shape optimization study of a high-speed train nose ...
Crespo Martínez, Antonio +2 more
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
AerospaceMost existing studies on aerodynamic shape optimization have not considered longitudinal trim under control surface deflection, typically achieving self-trim through a constraint of zero pitching moment or adjusting the optimized configuration for ...
Yacong Wu +3 more
doaj +1 more source
Aerodynamic design using numerical optimization [PDF]
The procedure of using numerical optimization methods coupled with computational fluid dynamic (CFD) codes for the development of an aerodynamic design is examined.
Chapman, G. T., Murman, E. M.
core +1 more source
Predictive Control for Alleviation of Gust Loads on Very Flexible Aircraft
, 2014 In this work the dynamics of very flexible aircraft are described by a set of non-linear, multi-disciplinary equations of motion. Primary structural components are represented by a geometrically-exact composite beam model which captures the large dynamic
Chen P. +8 more
core +1 more source
A New Cokriging Method for Variable-Fidelity Surrogate Modeling of Aerodynamic Data [PDF]
, 2010 Cokriging is a statistical interpolation method for the enhanced prediction of a less intensively sampled primary variable of interest with assistance of intensively sampled auxiliary variables. In the geostatistics community it is referred to as two- or
Görtz, Stefan +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Optimization and design of three-dimensional aerodynamic configurations of arbitrary shape by a vortex lattice method [PDF]
A new method based on vortex lattice theory has been developed which can be applied to the combined analysis, induced drag optimization, and aerodynamic design of three-dimensional configurations of arbitrary shape.
Feifel, W. M.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source