Results 61 to 70 of about 10,735,463 (237)

Integrated Surrogate Model-Based Approach for Aerodynamic Design Optimization of Three-Stage Axial Compressor in Gas Turbine Applications

Energies
The refined aerodynamic design optimization of multistage compressors is a typical high-dimensional and expensive optimization problem. This study proposes an integrated surrogate model-assisted evolutionary algorithm combined with a Directly Manipulated
Jinxin Cheng, Bin Li, Xiancheng Song, Xinfang Ji, Yong Zhang, Jiang Chen, Hang Xiang   +6 more
doaj   +1 more source

Geometry Design Optimization of a Wind Turbine Blade Considering Effects on Aerodynamic Performance by Linearization

Energies, 2020
For a wind turbine to extract as much energy as possible from the wind, blade geometry optimization to maximize the aerodynamic performance is important.
Kyoungboo Yang
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Topology optimisation: increasing the speed and reliability of design [PDF]

, 2014
In this paper, topology optimisation is applied to the design of the rear fuselage of an unmanned aerial vehicle (UAV). A comparison is drawn between the performance of a design created through evolutionary structural optimisation (ESO) and a baseline ...
Andy Keane, Keane, Andy J., Sobester, Andras, Liam M. Kelly, Andras Sobester, Kelly, Liam, David Toal, Toal, David J.J.   +7 more
core   +1 more source

Application of Multidisciplinary Design Optimization on Advanced Configuration Aircraft

Journal of Aerospace Technology and Management, 2017
An optimization strategy is constructed to solve the aerodynamic and structural optimization problems in the conceptual design of double-swept flying wing aircraft. Aircraft preliminary aerodynamic and structural design optimization is typically based on
Yalin Pan, Jun Huang, Feng Li, Chuxiong Yan   +3 more
doaj  

Accelerated Airfoil Optimization via a Geometry-Based Discriminator Within Particle Swarm Optimization

IEEE Access
Particle swarm optimization (PSO) is widely used for aerodynamic shape optimization; however, its practical efficiency is often limited by the high computational cost of aerodynamic evaluations and the frequent generation of geometrically unrealistic ...
Leul Walelign Michael, Abdulazez Abagero, Abera Tullu, Yoseph Mekonnen Abebe, Sunghun Jung   +4 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Efficient aerodynamic shape optimization by using unsupervised manifold learning to filter geometric features

Engineering Applications of Computational Fluid Mechanics
Many aerodynamic shape optimization methods often focus on utilizing the end-to-end relationship between design variables and aerodynamic performance to find the optimal design, while overlooking the exploration of geometric knowledge of the shape itself.
Long Ma, Xiao-Jing Wu, Wei-Wei Zhang
doaj   +1 more source