Results 81 to 90 of about 10,735,463 (237)
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Turbomachinery aerodynamic and aeromechanic design optimization using the adjoint method [PDF]
, 2008 The thesis documents the investigation of the application of the adjoint method to turbomachinery blading design optimization, with emphasis on blading aerodynamic design optimization in a multi-bladerow environment and concurrent blading aerodynamic and
Wang, Dingxi
core
Transonic Buffet Suppression by Airfoil Optimization
AerospaceThe main buffet suppression techniques of aircrafts include active and passive flow control, aiming to reduce the impact of the fluctuating loads on the airfoil. These techniques are remedies after the airfoil design. The buffet suppression is not always
Yiming Gong +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Efficient polar optimization of transport aircraft in transonic RANS flow using adjoint gradient based approach [PDF]
, 2012 A major design requirement for transport aircraft is efficient cruise flight in the transonic region. From the aerodynamic viewpoint, this is achieved by favorable lift-to-drag ratio of the aircraft, both at the main design point and at off-design ...
Brezillon, Joel +2 more
core
MathematicsConsidering the influence of high-speed obstacle avoidance trajectory in the optimization design stage of intelligent bus aerodynamic shape. A collaborative optimization method aiming at aerodynamic structure and trajectory control system for intelligent
Tingting Wang +5 more
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source