Versatile vector tools for efficient protein screening across multiple expression systems
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
A novel shape optimization method using knot insertion algorithm in B-spline and its application to transonic airfoil design [PDF]
A new method using the cubic B-spline curves with nominal uniform knot set to parameterize the geometry is proposed to deal with shape optimization problems.
Xu, B. +4 more
core +1 more source
Rapid design method of rocket aerodynamic shape based on conditional diffusion model
Aerodynamic design plays a vital role in rocket design. To expedite the design process of rocket aerodynamic shapes and minimize tedious iterative optimization, this study proposes a generative rapid inverse design method for rocket aerodynamic shapes ...
Chuan Li +5 more
doaj +1 more source
Aerodynamic Optimization of a Winglet Design
In the present study, an experimental study is presented for a flow around an isolated wing equipped by a winglet and profiled with Naca 0012. Several cases of winglets were tested according to the angle ß: 0°, 55°, 65°and 75°.
Yahiaoui T. +3 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Comparison between Gradient-free and Adjoint Based Aerodynamic Optimization of a Flying Wing Transport Aircraft in the Preliminary Design. [PDF]
This paper describes investigations of planform and shape optimizations for a flying wing transport aircraft with an Euler continuous adjoint method.
Arno, Ronzheimer +2 more
core
Optimization techniques with knowledge based control in ship concept design [PDF]
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.An integrated computational approach to Ship Concept Design using optimization techniques and a knowledge base to control the optimization process has been ...
Schachter, Richard David
core +4 more sources
The aerodynamic configuration of an aircraft determines its shape and directly influences flight performance, platform functionality, and mission effectiveness. In modern aircraft development, increasing performance demands and technical complexity cause
Zhenghong Gao, Chengjun He, Lin Zhou
doaj +1 more source

