Results 51 to 60 of about 15,229 (267)

Rapid design method of rocket aerodynamic shape based on conditional diffusion model

Kongqi donglixue xuebao
Aerodynamic design plays a vital role in rocket design. To expedite the design process of rocket aerodynamic shapes and minimize tedious iterative optimization, this study proposes a generative rapid inverse design method for rocket aerodynamic shapes ...
Chuan Li, Jiandong Chen, Lei He, Ming Cheng, Weiqi Qian, Jiazhe Lin   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

ASPIRE Aerodynamic Models and Flight Performance [PDF]

AIAA Aviation 2019 Forum, 2019
The Advanced Supersonic Parachute Inflation Research Experiments (ASPIRE) project waslaunched to develop the capability for testing supersonic parachutes at Mars-relevant conditions.Three initial parachute tests, targeted as a risk-reduction activity for NASA's upcomingMars2020 mission, successfully tested two candidate parachute designs and provided ...
Suman Muppidi, Clara O'Farrell, John W. Van Norman, Ian G. Clark   +3 more
openaire   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Numerical simulation of airfoil aerodynamic performance under the coupling effects of heavy rain and ice accretion

Advances in Mechanical Engineering, 2016
It has been widely investigated before that both heavy rain and icing conditions can cause severe aerodynamic performance penalties to aircraft in flight; however, aircraft aerodynamics in the presence of both heavy rain and ice accretion has been little
Zhenlong Wu, Yihua Cao
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Visual Explainable Convolutional Neural Network for Aerodynamic Coefficient Prediction

International Journal of Aerospace Engineering, 2022
Recently, aerodynamic performance analysis has been widely studied due to its importance in aircraft design. Most works adopted computational fluid dynamics (CFD) simulation to compute the aerodynamic forces, which is time consuming.
Yanxuan Zhao, Chengwen Zhong, Fang Wang, Yueqing Wang   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Role of Partial Flexibility on Flow Evolution and Aerodynamic Power Efficiency over a Turbine Blade Airfoil

Aerospace
In this study, the aerodynamic performance of a cambered wind turbine airfoil with a partially flexible membrane material on its suction surface was examined experimentally across various angles of attack and Reynolds numbers.
Kemal Koca, Mustafa Serdar Genç
doaj   +1 more source