Results 91 to 100 of about 41,589 (237)

Adjoint-Based Design of a Distributed Propulsion Concept with a Power Objective [PDF]

The adjoint-based design capability in FUN3D is extended to allow efficient gradient-based optimization and design of concepts with highly integrated and distributed aero-propulsive systems.
Diskin, Boris, Nielsen, Eric J., Ordaz, Irian, Rallabhandi, Sriram K.   +3 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Manifold Learning for Aerodynamic Shape Design Optimization

Aerospace
The significant computational cost incurred due to the iterative nature of Computational Fluid Dynamics (CFD) in traditional aerodynamic shape design frameworks poses a major challenge, especially in the context of modern integrated design requirements ...
Boda Zheng, Abhijith Moni, Weigang Yao, Min Xu   +3 more
doaj   +1 more source

A New Cokriging Method for Variable-Fidelity Surrogate Modeling of Aerodynamic Data [PDF]

, 2010
Cokriging is a statistical interpolation method for the enhanced prediction of a less intensively sampled primary variable of interest with assistance of intensively sampled auxiliary variables. In the geostatistics community it is referred to as two- or
Görtz, Stefan, Han, Zhong-Hua, Zimmermann, Ralf   +2 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Sail optimization for upwind sailing: application in a Tornado, the Olympic class catamaran.

, 2008
A study of a boat’s motion is carried out in order to analyze the aerodynamic properties of the optimal sail for obtaining the maximum velocity when sailing to windward.
Ana Laverón-Simavilla, Angel Sanz, CA Marchaj, CJ Wood, JA Sparenberg, NJ Locke, PS Jackson, RGJ Flay, RGJ Flay, Sebastián Franchini, T Sugimoto, Victoria Lapuerta   +11 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

An Improved Approach for Reducing the Dimensionality of Wing Aerodynamic Optimization Considering Longitudinal Stability

Aerospace
The wing aerodynamic shape optimization is a typical high-dimensional problem with numerous independent design variables. Researching methods to reduce the dimensionality of optimization from the perspective of aerodynamic characteristics is necessary ...
Boqian Ji, Jun Huang, Xiaoqiang Lu, Yacong Wu, Jingjiang Liu   +4 more
doaj   +1 more source

Numerical Airfoil Optimization Using a Reduced Number of Design Coordinates [PDF]

A method is presented for numerical airfoil optimization whereby a reduced number of design coordinates are used to define the airfoil shape. The approach is to define the airfoil as a linear combination of shapes.
Hicks, R. M., Vanderplaats, G. N.
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source