Results 71 to 80 of about 3,498,285 (189)

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Aerodynamic Shape Optimization of a Missile Using a Multiobjective Genetic Algorithm

International Journal of Aerospace Engineering, 2020
The aim of this paper is to demonstrate the effects of the shape optimization on the missile performance at supersonic speeds. The N1G missile model shape variation, which decreased its aerodynamic drag and increased its aerodynamic lift at supersonic ...
Ahmet Şumnu, İbrahim Halil Güzelbey, Orkun Öğücü   +2 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Manifold Learning for Aerodynamic Shape Design Optimization

Aerospace
The significant computational cost incurred due to the iterative nature of Computational Fluid Dynamics (CFD) in traditional aerodynamic shape design frameworks poses a major challenge, especially in the context of modern integrated design requirements ...
Boda Zheng, Abhijith Moni, Weigang Yao, Min Xu   +3 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Efficient polar optimization of transport aircraft in transonic RANS flow using adjoint gradient based approach [PDF]

, 2012
A major design requirement for transport aircraft is efficient cruise flight in the transonic region. From the aerodynamic viewpoint, this is achieved by favorable lift-to-drag ratio of the aircraft, both at the main design point and at off-design ...
Brezillon, Joel, Ilic, Caslav, Widhalm, Markus   +2 more
core  

Surrogate Based Optimization of Aerodynamic Noise for Streamlined Shape of High Speed Trains

, 2017
Aerodynamic noise increases with the sixth power of the running speed. As the speed increases aerodynamic noise becomes predominant and begins to be the main noise source at a certain high speed.
孙振旭, 杨国伟, Zhang Y, Sun, ZX (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China.   +3 more
core   +1 more source

Multi-disciplinary shape optimization of an entry capsule integrated with custom neural network approximation and multi-delity approach [PDF]

, 2011
This paper describes a new integrated approach for the multi-disciplinary optimization of a entry capsule’s shape. Aerothermodynamics, Flight Mechanics and Thermal Protection System behaviour of a reference spaceship when crossing Martian atmosphere are ...
Gallizio, Federico, Mareschi, Vincenzo, Davite, Alessio, Minisci, Edmondo, Chiarelli, Cosimo, Cavallero, Claudio, Sudars, Martins   +6 more
core   +3 more sources

Integrated Aerodynamic Shape and Aero-Structural Optimization: Applications from Ahmed Body to NACA 0012 Airfoil and Wind Turbine Blades

Fluids
During this research, aerodynamic shape optimization is conducted on the Ahmed body with the drag coefficient as the objective function and the ramp shape as the design variable, while aero-structural optimization is conducted on NACA 0012 to reduce the ...
Sagidolla Batay, Aigerim Baidullayeva, Erkhan Sarsenov, Yong Zhao, Tongming Zhou, Eddie Yin Kwee Ng, Taldaubek Kadylulu   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source