Results 81 to 90 of about 41,589 (237)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Two-Stage Multi-Objective Optimization for Improving the Aerodynamic Characteristics of High-Speed Train Nose Shape

Fluids
An optimal high-speed train nose design was formulated to reduce aerodynamic drag, mitigate tunnel micro-pressure waves, and improve crosswind safety. Using the vehicle modeling function, the EMU-320 nose shape was derived and applied as the base model ...
Suhwan Yun, Minho Kwak, Hyungmin Kang, Wonhee Park, Taesoo Kwon   +4 more
doaj   +1 more source

Aerodynamic Shape Optimization of a Missile Using a Multiobjective Genetic Algorithm

International Journal of Aerospace Engineering, 2020
The aim of this paper is to demonstrate the effects of the shape optimization on the missile performance at supersonic speeds. The N1G missile model shape variation, which decreased its aerodynamic drag and increased its aerodynamic lift at supersonic ...
Ahmet Şumnu, İbrahim Halil Güzelbey, Orkun Öğücü   +2 more
doaj   +1 more source

Optimization and design of three-dimensional aerodynamic configurations of arbitrary shape by a vortex lattice method [PDF]

A new method based on vortex lattice theory has been developed which can be applied to the combined analysis, induced drag optimization, and aerodynamic design of three-dimensional configurations of arbitrary shape.
Feifel, W. M.
core   +1 more source

A computational assessment of the aerodynamic performance of a tilted Darrieus wind turbine [PDF]

, 2015
The aerodynamic performance of a Darrieus wind turbine operating with the rotation axis tilted with respect to the free-stream wind speed is investigated in this paper. An Unsteady Reynolds Averaged Navier Stokes (URANS) Computational Fluid Dynamics (CFD)
Bedon, Gabriele, Benini, Ernesto, DE BETTA, Stefano   +2 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Data-driven aerodynamic shape optimization of rotor airfoils based on deep learning

Advances in Aerodynamics
As the fundamental component of rotor blades, the airfoil dominates the aerodynamic performance of helicopter rotors. The aerodynamic shape optimization of rotor airfoils is thus an effective means of improving their aerodynamic performance.
Jiaqi Liu, Rongqian Chen, Jinhua Lou, Yancheng You   +3 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Integrated Aerodynamic Shape and Aero-Structural Optimization: Applications from Ahmed Body to NACA 0012 Airfoil and Wind Turbine Blades

Fluids
During this research, aerodynamic shape optimization is conducted on the Ahmed body with the drag coefficient as the objective function and the ramp shape as the design variable, while aero-structural optimization is conducted on NACA 0012 to reduce the ...
Sagidolla Batay, Aigerim Baidullayeva, Erkhan Sarsenov, Yong Zhao, Tongming Zhou, Eddie Yin Kwee Ng, Taldaubek Kadylulu   +6 more
doaj   +1 more source