Results 51 to 60 of about 21,740 (297)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
The Aerodynamics of Reacting Substances [PDF]
Proceedings of the National Academy of Sciences, 1939 Speaking broadly, the subject of aerodynamics is concerned not only with the forces exerted by a single fluid on solid bodies but also with the behavior of mixtures such as those which occur in the gasoline engine and in the atmosphere. In a complete study of the motion of a fluid attention must be paid to reactions between its constituents ...
openaire +4 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Crystals, 2023 In-cloud icing occurred on cables, wind turbines, and aircraft wings and may cause power transmission paralysis, energy dissipation, and unsafe flight.
Ruidi Liu, Yu Liu, Qiang Wang, Xian Yi
doaj +1 more source
AerospaceTo clarify the influence of the serpentine nozzle configurations on the flow characteristics and aerodynamic performance of aircraft, the flow features and aerodynamic performances of the double-ducted serpentine nozzles with different aspect ratios (AR),
Jilong Zhu +6 more
doaj +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Multi-Fidelity Aerodynamic Data Fusion with a Deep Neural Network Modeling Method
Entropy, 2020 To generate more high-quality aerodynamic data using the information provided by different fidelity data, where low-fidelity aerodynamic data provides the trend information and high-fidelity aerodynamic data provides value information, we applied a deep ...
Lei He, Weiqi Qian, Tun Zhao, Qing Wang
doaj +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Transonic Static Aeroelastic Numerical Analysis of Flexible Complex Configuration Wing
Shock and Vibration, 2021 Diamond back wing is subjected to large deformation while gliding, which significantly changes characteristics of the lift as well as the static stability.
Changrong Zhang +4 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source