Results 71 to 80 of about 21,740 (297)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Study on the Similarity Criteria of Aircraft Structure Temperature/Stress/Dynamic Response
Journal of Thermal Science and Technology, 2012 The performance parameters of thermal protection system are essential for the design and optimization of high-speed aircraft. The flight-ground conversion is a valid method to provide the effective support to the design of the thermal protection ...
Lei LIU +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
An implicit parallel UGKS solver for flows covering various regimes
Advances in Aerodynamics, 2019 This paper presents an engineering-oriented UGKS solver package developed in China Aerodynamics Research and Development Center (CARDC). The solver is programmed in Fortran language and uses structured body-fitted mesh, aiming for predicting aerodynamic ...
Dingwu Jiang +3 more
doaj +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Aerodynamic Behavior of Inclined Circular Cylinders-Cable Aerodynamics
Wind Engineers, JAWE, 1988 This study attempts to clarify of the mechanism of rain-wind induced vibration of the stay cables of a cable stayed bridge and to find an effective aerodynamic stabilization method. Through a series of wind tunnel tests the fundamental aerodynamic characteristics of a yawed and/or inclined circular Cylinder with and without rain were investigated.
Naruhito Shiraishi +6 more
openaire +4 more sources
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Simulation on Buffet Response and Mitigation of Variant-Tailed Aircraft in Maneuver State
VibrationThis study proposes a computational fluid dynamics and computational structure dynamics (CFD/CSD) coupled method for calculating the buffet response of a variant tail wing.
Dawei Liu +6 more
doaj +1 more source
The aerodynamics of sailing apparel
Procedia Engineering, 2012 AbstractThe paper presents the effect of changes in sailing apparel on aerodynamic drag, starting from the assumption that drag reduction of sailing apparel will increase the speed of an Olympic class sailing boat (in this case the Laser, a single-handed Olympic dinghy), mainly on upwind courses. Due to the fact that literature on this specific subject
Jansen, A.J. (author) +2 more
openaire +4 more sources