Results 171 to 180 of about 503,882 (291)

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

Advanced Science, EarlyView.
This study uncovers a tri‐directional interplay among cells, hydrogels, and their nascent extracellular matrix. Hydrogel norbornene modification alters CD44‐mediated cell–hydrogel interactions, which shape nascent matrix deposition, composition, and spatial organization.
Joshua Y. Liu, Ziqian Yang, Arina E. Velieva, Eleanor M. Plaster, Mingyue Fan, Donia W. Ahmed, Avinava Roy, Pamela Duran, Pamela Panovich, Alexandra S. Piotrowski‐Daspit, Carlos A. Aguilar, Megan L. Killian, Claudia Loebel   +12 more
wiley   +1 more source

Therapeutic Interventions in Niemann-Pick Disease Type C: A Systematic Review of Clinical Outcomes and Safety. [PDF]

Biomedicines
Nafees Z, Mohammed SSN, Bernhardt GV, Kumar S.   +3 more
europepmc   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Corrigendum to “Could acute Q fever be causing some cases of pediatric acute encephalitis syndrome in eastern Uttar Pradesh?” [Microbe 5 (2024) 100203]

The Microbe
Shahzadi Gulafshan, Pooja Bhardwaj, Rohit Beniwal, Vishal Yadav, Rajni Kant, Kamran Zaman, Mahim Mittal, Bhoopendra Sharma, Vijai Kumar Srivastava, Rajeev Singh   +9 more
doaj   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

Safety assessment of ambrisentan based on the FDA Adverse Event Reporting System. [PDF]

Medicine (Baltimore)
Dan Y, Xu G, Chen H, Li H, Hu B.
europepmc   +1 more source

All the AES You Need on Cortex-M3 and M4

ACM Symposium on Applied Computing, 2016
P. Schwabe, Ko Stoffelen
semanticscholar   +1 more source

Intrinsic i$i$‐Wave Altermagnetism in 2D Graphene Superlattices

Advanced Science, EarlyView.
Altermagnetism has so far been mostly proposed in transition metals compounds. Here we show that monolayer and bilayer graphene antidot superlattices realize a carbon‐based i‐wave altermagnet. This is demonstrated with a combination of symmetry analysis, first principles methods and effective models, featuring a six‐fold spin splitting texture in ...
Cuiju Yu, Jose L. Lado
wiley   +1 more source

Pharmacovigilance in the treatment of cutaneous leishmaniasis: adverse event profile at a reference center. [PDF]

Rev Soc Bras Med Trop
Rezende ALS, Carvalho JP, Noronha BP, Silva SN.   +3 more
europepmc   +1 more source