Results 101 to 110 of about 20,026 (197)

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

Cell Reports, 2013
The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans ...
Adam C. Wilkinson, Erica Ballabio, Huimin Geng, Phillip North, Marta Tapia, Jon Kerry, Debabrata Biswas, Robert G. Roeder, C. David Allis, Ari Melnick, Marella F.T.R. de Bruijn, Thomas A. Milne   +11 more
doaj   +1 more source

Exploring viewpoint in The Tempest: exemplification level 5 (Active Shakespeare: Capturing evidence of learning) [PDF]

, 2010
Part of the 'Active Shakespeare: Capturing evidence of learning' suite of resources. "What is it about Providing active and engaging ways to integrate Shakespeare in the ongoing periodic assessment of pupils’ reading. What is it for?

core  

Exploring the soliloquies of Romeo and Juliet: teacher notes (Active Shakespeare: Capturing evidence of learning) [PDF]

, 2010
Part of the 'Active Shakespeare: Capturing evidence of learning' suite of resources. "What is it about Providing active and engaging ways to integrate Shakespeare in the ongoing periodic assessment of pupils’ reading. What is it for?

core  

Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia

Advances in Hematology, 2011
Translocation t(4;11)(q21;q23) leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL) in adult patients.
F. Marchesi, K. Girardi, G. Avvisati
doaj   +1 more source

MLL-AF4+ infant leukemia: a microRNA affair [PDF]

Blood, 2021
openaire   +2 more sources

MLL-AF4 driven leukemogenesis: what are we missing? [PDF]

Cell Research, 2012
Infant pro-B acute lymphoblastic leukemia (ALL) harboring MLL-AF4 fusion proteins instigated by chromosomal translocation t(4;11), represents an aggressive, high-risk type of childhood leukemia, characterized by a very brief disease latency and undisputedly originates in utero.
openaire   +2 more sources

The therapeutic response and clinical outcome of adults with ALL1(MLL)/AF4 fusion positive acute lymphoblastic leukemia according to the GIMEMA experience

Haematologica, 2010
The clinical outcome of 21 adults with ALL1(MLL)/AF4 positive acute lymphoblastic leukemia enrolled in the GIMEMA LAL 2000 trial and of 25 patients entered into the previous 0496 study is reported.
Giuseppe Cimino, Natalia Cenfra, Loredana Elia, Simona Sica, Mario Luppi, Giovanna Meloni, Marco Vignetti, Francesca Paoloni, Robin Foà, Franco Mandelli   +9 more
doaj   +1 more source

Parâmetros genéticos para produção de leite no dia do controle de vacas da raça Holandesa utilizando modelos de análises de fatores e componentes principais

Ciência Rural, 2015
Objetivou-se comparar um modelo multi-característica padrão com modelos de análise de fatores (AF) e de componentes principais (CP) para estimar parâmetros genéticos para a produção de leite no dia do controle (PLDC) de vacas da raça Holandesa. O arquivo
Mariana de Almeida Dornelles, Paulo Roberto Nogara Rorato, Fernanda Cristina Breda, Carlos Bondan, Luis Telo Lavadinho da Gama, Jaime Araujo Cobuci, Giovani Luis Feltes, Vanessa Tomazetti Michelotti, Alan Miranda Prestes   +8 more
doaj   +1 more source

MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199

Cell Reports, 2015
Targeted therapies designed to exploit specific molecular pathways in aggressive cancers are an exciting area of current research. Mixed Lineage Leukemia (MLL) mutations such as the t(4;11) translocation cause aggressive leukemias that are refractory to ...
Juliana M. Benito, Laura Godfrey, Kensuke Kojima, Leah Hogdal, Mark Wunderlich, Huimin Geng, Isabel Marzo, Karine G. Harutyunyan, Leonard Golfman, Phillip North, Jon Kerry, Erica Ballabio, Triona Ní Chonghaile, Oscar Gonzalo, Yihua Qiu, Irmela Jeremias, LaKiesha Debose, Eric O’Brien, Helen Ma, Ping Zhou, Rodrigo Jacamo, Eugene Park, Kevin R. Coombes, Nianxiang Zhang, Deborah A. Thomas, Susan O’Brien, Hagop M. Kantarjian, Joel D. Leverson, Steven M. Kornblau, Michael Andreeff, Markus Müschen, Patrick A. Zweidler-McKay, James C. Mulloy, Anthony Letai, Thomas A. Milne, Marina Konopleva   +35 more
doaj   +1 more source

Study of the magnetic state of K$_{0.8}$Fe$_{1.6}$Se$_2$ using the five-orbital Hubbard model in the Hartree-Fock approximation

, 2011
Motivated by the recent discovery of Fe-based superconductors close to an antiferromagnetic insulator in the experimental phase diagram, here the five-orbital Hubbard model (without lattice distortions) is studied using the real-space Hartree-Fock ...
Dagotto, Elbio, Luo, Qinlong, Moreo, Adriana, Nicholson, Andrew, Riera, José, Yao, Dao-Xin   +5 more
core   +1 more source