Results 121 to 130 of about 7,188 (177)
Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery. [PDF]
Shalabalija D +7 more
europepmc +1 more source
Assessment of biophysical properties of the first-in-class anti-cancer IgE antibody drug MOv18 IgE demonstrates monomeric purity and stability. [PDF]
Considine P +11 more
europepmc +1 more source
Mediation of Af4 function in the cerebellum by Siah proteins
Bitoun, E, Oliver, P, Davies, K
openaire +1 more source
t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL [PDF]
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
Ashish Kumar, John H Kersey
exaly +3 more sources
Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? [PDF]
The human AF4 (ALL-1 fused gene on chromosome 4) gene (4q11) is recurrently involved in reciprocal translocations to the MLL (mixed lineage leukemia) gene (11q23), correlated with high-risk acute lymphoblastic leukemia (ALL) in infants and early childhood. The t(4;11) translocation is one of the most frequent MLL translocations known today. In general,
Rolf Marschalek, Marschalek Rolf
exaly +4 more sources
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Blood, 1998
Abstract Acute leukemia with t(4;11)(q21,q23) translocation results from the in-frame fusion of the MLL to the AF4/FEL gene. In previous studies, we and others demonstrated that AF4 transcripts are present in a variety of hematopoietic and nonhematopoietic human cells.
Q, Li, J L, Frestedt, J H, Kersey
openaire +2 more sources
Abstract Acute leukemia with t(4;11)(q21,q23) translocation results from the in-frame fusion of the MLL to the AF4/FEL gene. In previous studies, we and others demonstrated that AF4 transcripts are present in a variety of hematopoietic and nonhematopoietic human cells.
Q, Li, J L, Frestedt, J H, Kersey
openaire +2 more sources
Differential expression of AF4/FEL mRNA in human tissues
Genetic Analysis, Techniques and Applications, 1996This manuscript reports the differential expression of the AF4 gene among human tissues. AF4 mRNA is highly expressed in normal placental tissue which correlates with the newborn age of patients presenting with leukemia characterized by the MLL/AF4 gene rearrangement.
Joy Frestedt, John H Kersey, J M Hilden
exaly +3 more sources

