Results 31 to 40 of about 526 (116)

An overview of the cutaneous porphyrias [version 1; referees: 2 approved]

F1000Research, 2017
This is an overview of the cutaneous porphyrias. It is a narrative review based on the published literature and my personal experience; it is not based on a formal systematic search of the literature.
Robert Dawe
doaj   +1 more source

Etiopathogenesis and Emerging Methods for Treatment of Vitiligo

, 2023
Vitiligo is an acquired chronic depigmenting disorder of skin. It is mostly asymptomatic and characterized by amelanotic macules and patches that affects 0.5% to 2% of the world’s population. The etiology of vitiligo has not been clearly elucidated
Roman Janusz Nowicki, Tomasz Iwanowski, Małgorzata Sokołowska-Wojdyło, Karol Kołkowski   +3 more
core   +1 more source

Melanocortin receptors in GtoPdb v.2023.1 [PDF]

, 2023
Melanocortin receptors (provisional nomenclature as recommended by NC-IUPHAR [41]) are activated by members of the melanocortin family (α-MSH, β-MSH and γ-MSH forms; δ form is not found in mammals) and adrenocorticotrophin (ACTH ...
Gantz, Ira, Carrie Haskell-Luevano, Haskell-Luevano, Carrie, Wikberg, Jarl E. S., Adrian J. L. Clark, Schiöth, Helgi, Colin Pouton, Pouton, Colin, Mountjoy, Kathleen G., Roger D. Cone, Jeffrey B. Tatro, Cone, Roger D., Chai, Biao-Xin, Tatro, Jeffrey B., Ira Gantz, Clark, Adrian J. L., Tung M. Fong, Jarl E. S. Wikberg, Vanni Caruso, Biao-Xin Chai, Caruso, Vanni, Fong, Tung M., Eberle, Alex N., Alex N. Eberle, Sadaf Farooqi, Kathleen G. Mountjoy, Helgi Schiöth, Farooqi, Sadaf, Hruby, Victor J., Victor J. Hruby   +29 more
core   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

The effects of cholecalciferol and afamelanotide on vitamin D levels in erythropoietic protoporphyria:a multicentre cohort study [PDF]

Background: Patients with erythropoietic protoporphyria experience lifelong painful photosensitivity resulting in a lack of sunlight exposure. Previous studies have shown that 47-63% of patients with EPP suffer from vitamin D deficiency and a high ...
Nekouei Shahraki, Mitra, Wagenmakers, Margreet A.E.M., Kluijver, Louisa G., Hanssen, Bettina E., Langendonk, Janneke G.; id_orcid, Homey, Bernhard, Kuerten, Viola, Schelonke, Kathrin   +7 more
core   +1 more source

Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis, Ioanna Saougou, Eleftheria Hatzimichael   +2 more
wiley   +1 more source

Vitiligo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 8, Page 968-987, August 2025.
Summary Vitiligo is a common pigment disorder of the skin resulting in destruction of melanocytes. Non‐segmental vitiligo (NSV) is an autoimmune disorder. The etiopathogenesis of segmental vitiligo (SV) remains incompletely understood. Genetic predisposition and increased vulnerability of melanocytes towards stressors lead to a melanocyte‐specific CD8+
Markus Böhm, Adrian Tanew
wiley   +2 more sources

Isopropanol‐Dimethyl Sulfoxide, as a Green Solvent Mixture for Solid‐Phase Peptide Synthesis

Chemistry–Methods, Volume 6, Issue 5, May 2026.
IPA–DMSO represents a practical and greener solvent platform for SPPS. The increasing industrial demand for peptide therapeutics, together with regulatory and societal pressure to improve the sustainability of chemical processes, has accelerated efforts to replace hazardous solvents used in solid‐phase peptide synthesis (SPPS).
Sikabwe Noki, Rajan Sharma, Beatriz G. de la Torre, Hossain Saneii, Fernando Albericio   +4 more
wiley   +1 more source

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source

An Original PEG‐Functionalized PS Resin Enables Synthesis of Difficult Peptides: Application to Tirzepatide

ChemistrySelect, Volume 11, Issue 6, 12 February 2026.
The Seplife Fmoc‐RinkAmide‐PS‐PEG resin, a PEG‐grafted PS resin with optimized composition enables improved swelling and higher loading for SPPS. This resin delivers efficient couplings and high crude purities, supporting reliable synthesis of long and complex peptides.
Ashish Kumar, Peter K. Kabwe, Mahama Alhassan, Wei Hou, Chaoyang Wang, Cheng Zhang, Yanjun Li, Xiaokang Kou, Simona Serban, Alessandra Basso, Anamika Sharma, Beatriz G. De La Torre, Fernando Albericio   +12 more
wiley   +1 more source