Results 201 to 210 of about 4,712,758 (317)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Efficacy of Coping with Negative Affect via Alcohol Use Pre- and Post Acute Stress. [PDF]
Behav Sci (Basel)Willis MA, Ran T, Lane SP.
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Acculturation Gap Conflict and Self-Control Mediate the Association Between Negative Affect and Sleep Problems for Hispanic/Latino(a) Adolescents. [PDF]
Int J Environ Res Public HealthBruzos MJ +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Bright light exposure reduces negative affect and modulates EEG activity in sleep-deprived and well-rested adolescents. [PDF]
Front Behav NeurosciKopřivová J +7 more
europepmc +1 more source
Will peer-to-peer online lending affect the effectiveness of monetary policy?
Chi‐Wei Su +3 more
openalex +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Significant influence of low positive affect on pain: impact of COVID-19 on affect and daily chronic non-cancer pain trajectories in women. [PDF]
Front Pain Res (Lausanne)Kuper QTY +6 more
europepmc +1 more source