Frontiers in Public Health, 2016 While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk.
Konstantin G. Arbeev +10 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Behavioral SciencesChronic disfiguring skin conditions profoundly affect patients’ quality of life (QoL) due to their physical, psychological, and emotional consequences.
Tonia Samela +8 more
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Emotion Dysregulation in College Students: Contributions of Maladaptive Personality Traits and Momentary Affect [PDF]
Emotion regulation involves behavioral modulation of emotional expression across contexts and is highly relevant to the experience of psychopathology. Maladaptive personality traits may be particularly relevant individual differences for understanding ...
Leiana de la Paz +3 more
core
Affect Dysregulation As A Mediator Of The Relationship Between Childhood Trauma And Comorbid Substance Use Disorder And Bulimia Nervosa [PDF]
, 2014 Eating disorders are serious, potentially life-threatening psychiatric disorders associated with a variety of negative medical, social, and psychological consequences.
Crawford, Brianna Joelle
core +1 more source
Factors Associated with Co-Occurring Borderline Personality Disorder Among Inner-City Substance Users: The Roles of Childhood Maltreatment, Negative Affect Intensity/Reactivity, and Emotion Dysregulation [PDF]
, 2008 The co-occurrence of borderline personality disorder (BPD) among individuals with substance use disorders is a common and clinically relevant phenomenon in need of further empirical investigation.
Tull, Matthew T +4 more
core +1 more source
PRESCHOOL-AGE OBSERVATIONS OF DYSREGULATED POSITIVE AFFECT AND PARENT-REPORTED DYSREGULATION IN POSITIVE AFFECT PREDICT OVERALL ADOLESCENT EMOTION DYSREGULATION [PDF]
Journal of the American Academy of Child & Adolescent Psychiatry, 2021 Alecia Vogel +3 more
openaire +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Anhedonia, positive affect dysregulation, and risk and maintenance of binge-eating disorder. [PDF]
Int J Eat Disord, 2021 Mason TB +3 more
europepmc +1 more source