Results 91 to 100 of about 282,049 (291)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Nature Communications, 2019
Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.
Mingjing Hu, David Eviston, Peter Hsu, Eliana Mariño, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L. Richards, Yu Anne Yap, Fiona Collier, Ann Quinton, Steven Joung, Michael Peek, Ron Benzie, Laurence Macia, David Wilson, Ann-Louise Ponsonby, Mimi L. K. Tang, Martin O’Hely, Norelle L. Daly, Charles R. Mackay, Jane E. Dahlstrom, The BIS Investigator Group, Peter Vuillermin, Ralph Nanan   +24 more
doaj   +1 more source

The relationship between impulsivity, affect and a history of psychological adversity: a cognitive-affective neuroscience approach

, 2011
There is increasing evidence that trauma exposure is associated with impulsive behaviour and difficulties regulating affect. The findings of recent studies implicate the disruption of neurobiological mechanisms, particularly those involving the ...
Ipser, Jonathan
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Predictors of Drinking and Alcohol-Related Problems in College Women: Affect Dysregulation and Alcohol Expectancies

, 2008
The current study investigated the influences of positive alcohol expectancies, affect dysregulation, and trait affect on drinking intensity and alcohol-related problems in college women.
Garay, Miranda Michele
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Optimal versus Realized Trajectories of Physiological Dysregulation in Aging and their Relation to Sex-Specific Mortality Risk

Frontiers in Public Health, 2016
While longitudinal changes in biomarker levels and their impact on health have been characterized for individual markers, little is known about how overall marker profiles may change during aging and affect mortality risk.
Konstantin G. Arbeev, Alan A Cohen, Liubov S. Arbeeva, Emmanuel eMilot, Eric eStallard, Alexander M Kulminski, Igor eAkushevich, Svetlana eUkraintseva, Kaare eChristensen, Kaare eChristensen, Anatoliy I Yashin   +10 more
doaj   +1 more source

Additional file 1: of Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model

, 2018
Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load and glial activation in the J20 Alzheimer mouse model.
Ulrich Eisel (3226791), Ate Boerema (408974), Petrus Naudé (6034961), Doortje Dekens (6034952), Peter De Deyn (3523658), Jan Keijser (6034958)   +5 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Emotional Dysregulation, Hopelessness and Dysmorphophobic Concerns Among Hospitalized Patients with Autoimmune, Inflammatory, and Metabolic Skin Disorders

Behavioral Sciences
Chronic disfiguring skin conditions profoundly affect patients’ quality of life (QoL) due to their physical, psychological, and emotional consequences.
Tonia Samela, Giorgia Cordella, Valeria Antinone, Maria Beatrice Pupa, Alessandra Vendoni Capitani, Dario Didona, Luciana Di Girolamo, Anna Rita Giampetruzzi, Damiano Abeni   +8 more
doaj   +1 more source