Results 71 to 80 of about 282,049 (291)

Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder

Brain Sciences, 2020
Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined, neurodevelopmental disorder that has been modeled as a brain-based disease. The behavioral and cognitive features of ASD are associated with pervasive atypicalities in the central ...
Ahmad Naqib Shuid, Putri Ayu Jayusman, Nazrun Shuid, Juriza Ismail, Norazlin Kamal Nor, Isa Naina Mohamed   +5 more
doaj   +1 more source

Trait emotion dysregulation, momentary affect, and emotion regulation strategy use

, 2021
This study aims to assess the relationship between trait emotion dysregulation and momentary affective experiences and emotion regulation strategy use in daily ...
Devon Sandel-Fernandez, Jennifer Pearlstein, Benjamin Swerdlow, Sheri Johnson   +3 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impulsivity dimensions, emotion dysregulation, and borderline personality disorder features among Italian nonclinical adolescents

, 2014
BACKGROUND: Contemporary theorists have suggested that impulsivity and emotion dysregulation are two of the core features of BPD. The aim of this study was to evaluate the relationships between Borderline Personality Disorder (BPD) features, impulsivity,
Cesare Maffei, Gratz K. L, Serena Borroni, BORRONI , SERENA, Andrea Fossati, FOSSATI, ANDREA, MAFFEI , CESARE, Kim L Gratz   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Psychological intimate partner violence and childhood cumulative trauma: the mediating role of affect dysregulation, maladaptive personality traits, and negative urgency [PDF]

, 2018
The current study examined the mediating role of affect dysregulation, maladaptive personality traits, and negative urgency in the association between childhood cumulative trauma (CCT) and psychological intimate partner violence (IPV). A total of 241 men
Dugal, Caroline, Bélanger, Claude, Bates, Elizabeth, Sabourin, Stéphane, Girard, Marianne, Godbout, Natacha   +5 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Emotional Factors and Social Skills in Children with ADHD: The Roles of Anger Dysregulation and Temperamental Positive Affect

, 2021
ADHD is a common psychological disorder in children that is associated with social impairments as well as deficits in emotion regulation. Such emotion dysregulation often appears to contribute to social difficulties, and poor prosocial skills may play a ...
Ferrara, Erica Danielle
core