Results 81 to 90 of about 282,049 (291)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Affective dysregulation in pregnancy

, 2021
Affective symptoms (symptoms of depression and anxiety) are frequently seen during pregnancy. Pregnant women experience depression at a rate of 7-25 % of and anxiety disorders at a rate of 15 -22%. When pregnant women present with affective symptoms, it can have negative effects on their health and that of their (unborn) child.
openaire   +2 more sources

Parenting strategies: how they affect adolescents’ degree of life satisfaction

Journal of Clinical & Developmental Psychology, 2020
Background: According to Self Determination Theory (SDT) emotional self-regulation is a process of gradual acquisition of autonomous regulation capacity, which is influenced by both individual differences and social context in which the person is ...
Ilaria Meneghini, Claudia Aloisi, Clara Alosi, Liliana Arena, Valeria Barbagallo, Gabriele Berretta, Moira Biviano, Selene Billa, Maria Teresa Blando, Erika Bonaccorso, Marika Bottino, Lorenza Camarda, Nives Miriam Cassone, Ludovica Cerbone, Andrea Citrigno, Mihaela Kati Corsaro, Ludovica Corvaia, Chiara Costantino, Domenico Cotrone, Francesca Cutrì   +19 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

EMOTION DYSREGULATION AFFECTS FUNCTIONALITY IN MAJOR DEPRESSIVE DISORDER

Acibadem Universitesi Saglik Bilimleri Dergisi, 2023
Purpose: Mood disorders are recurrent chronic mental illnesses known to affect functionality. In this study, it was aimed to compare coping strategies and emotion regulation difficulties in depression and bipolar disorder and observe the effects of coping strategies and emotion regulation on functionality. Methods: 31 patients with bipolar ...
openaire   +2 more sources

Does emotion dysregulation mediate the relationship between behavioural inhibition and psychopathological symptoms?

, 2011
Failure to address poor mental health during childhood and adolescence results in higher risk of suicide, substance misuse, self-harm, and lower achievement in education and employment (Richards et al., 2009).
Willie, Anne
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Negative Mood Regulation (NMR) expectancies, mood, and affect intensity among clients in substance disorder treatment facilities [PDF]

, 2006
Negative mood regulation (NMR) expectancies, stress, anxiety, depression and affect intensity were examined by means of self-report questionnaires in 158 volunteers, including 99 clients enrolled in addiction treatment programs.
THORBERG, Fred Arne, Lyvers, Michael
core   +1 more source