Results 81 to 90 of about 284,310 (290)

Psychological intimate partner violence and childhood cumulative trauma: the mediating role of affect dysregulation, maladaptive personality traits, and negative urgency [PDF]

, 2018
The current study examined the mediating role of affect dysregulation, maladaptive personality traits, and negative urgency in the association between childhood cumulative trauma (CCT) and psychological intimate partner violence (IPV). A total of 241 men
Dugal, Caroline, Bélanger, Claude, Bates, Elizabeth, Sabourin, Stéphane, Girard, Marianne, Godbout, Natacha   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Object relations predicts borderline personality disorder symptoms beyond emotional dysregulation, negative affect, and impulsivity [PDF]

, 2017
Click on the DOI link to access the article (may not be free).Many studies have determined that the traits of emotional dysregulation, negative affect, and impulsivity are the strongest predictors of borderline personality disorder (BPD).
Albright, Jeremy J., Lengu*, Ketrin, Huprich, Steven K., Paggeot, Amy V., Paggeot*, Amy, Lengu, Ketrin J., Albright, Jeremy, Nelson, Sharon M.   +7 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Affective dysregulation in pregnancy

, 2021
Affective symptoms (symptoms of depression and anxiety) are frequently seen during pregnancy. Pregnant women experience depression at a rate of 7-25 % of and anxiety disorders at a rate of 15 -22%. When pregnant women present with affective symptoms, it can have negative effects on their health and that of their (unborn) child.
openaire   +2 more sources

EMOTION DYSREGULATION AFFECTS FUNCTIONALITY IN MAJOR DEPRESSIVE DISORDER

Acibadem Universitesi Saglik Bilimleri Dergisi, 2023
Purpose: Mood disorders are recurrent chronic mental illnesses known to affect functionality. In this study, it was aimed to compare coping strategies and emotion regulation difficulties in depression and bipolar disorder and observe the effects of coping strategies and emotion regulation on functionality. Methods: 31 patients with bipolar ...
openaire   +2 more sources

The role of attachment in adult mental health difficulties following the experience of childhood abuse [PDF]

, 2013
Child abuse is recognised to contribute to the development of adult mental health problems and personality disorders. The role of attachment in this relationship is widely acknowledged, but not well understood.
Selwood, Emma
core  

Parenting strategies: how they affect adolescents’ degree of life satisfaction

Journal of Clinical & Developmental Psychology, 2020
Background: According to Self Determination Theory (SDT) emotional self-regulation is a process of gradual acquisition of autonomous regulation capacity, which is influenced by both individual differences and social context in which the person is ...
Ilaria Meneghini, Claudia Aloisi, Clara Alosi, Liliana Arena, Valeria Barbagallo, Gabriele Berretta, Moira Biviano, Selene Billa, Maria Teresa Blando, Erika Bonaccorso, Marika Bottino, Lorenza Camarda, Nives Miriam Cassone, Ludovica Cerbone, Andrea Citrigno, Mihaela Kati Corsaro, Ludovica Corvaia, Chiara Costantino, Domenico Cotrone, Francesca Cutrì   +19 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Origins of antisocial behavior. Negative reinforcement and affect dysregulation of behavior as socialization mechanisms in family interaction [PDF]

, 1997
Click on the DOI link below to access the article (may not be free).Theoretical models specifying the contribution of two social-familial mechanisms, negative reinforcement and affect dysregulation, to the development of child antisocial behavior were ...
St. Peter, Carolyn, Schrepferman, Lynn M., Snyder, James J.   +2 more
core   +1 more source