Results 101 to 110 of about 335,963 (286)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Affective commitment to the employer brand: development and validation of a scale [PDF]

open access: yes, 2016
In recent years employer branding has become increasingly important as a source of sustainable competitive advantage. Companies are trying to engender affective commitment in the best employees in a global labor market.
Avello Iturriagagoitia, María   +3 more
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Beyond the Three-Component Model of Organizational Commitment [PDF]

open access: yes
Adding to empirically based critique in the last 15 years, this paper offers a critical conceptual analysis of the three-component model of organizational commitment in order to arrive at a unequivocal grounding of the concept in standard attitudinal ...
Olffen, W. van   +2 more
core   +1 more source

Perceived Underemployment Among The Foreign-Born: Its Outcomes And The Moderating Role Of Psychological Empowerment And Perceived Organizational Support [PDF]

open access: yes, 2014
In the present study the relationship between perceived underemployment and job attitudes such as job satisfaction, affective organizational commitment, and turnover intentions among foreign-born employees was examined.
Avcil Okuyucu, Ayse
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Analisis Pengaruh Persepsi Dukungan Organisasi sebagai Mediator antara Partisipasi Karyawan dalam Pengambilan Keputusan terhadap Kepuasan Kerja dan Komitmen Afektif Karyawan Non Manajerial di Perusahaan Fmcg Indonesia [PDF]

open access: yes, 2016
This study aims to analyze the influence of perceived organizational support as a mediator between employee participation in decision making toward job satisfaction and affective commitment of non managerial employees.
Puspaatmaja, S. (Sendy)   +1 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

The study of mentoring and leader-member exchange (LMX) on organisational commitment among auditors in Malaysia [PDF]

open access: yes, 2009
This study examines the relationship and the interaction of mentoring (psychosocial and career) with the four dimensions of LMX (affect, contribution, professional respect, and loyalty) on organisational commitment.
Khong, Kok Wei *, Leow, Kah Loong *
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

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