Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Factors Associated With Occupational Commitment of Secondary School Teachers in Kuala Lumpur [PDF]
This research was an attempt to study factors associated with the occupational commitment of secondary school teachers in Kuala Lumpur, Malaysia.
Khamis Ali, Ali
core
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Affective Commitment to Organizations: a Comparison Study of Reverse Mentoring Versus Traditional Mentoring Among Millennials [PDF]
A current topic of interest in management and organization research is the phenomenon of a generation shift in the workforce and how this shift will affect organizations in the near future.
Hechl, C. (Catrin)
core
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Muhammad Aamir Shafique Khan,1 Du Jianguo,1 Ahmed Abdul Hameed,2 Tehseen UL Mushtaq,2 Muhammad Usman2 1School of Management, Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Management Sciences, COMSATS University Islamabad,
Khan MAS +4 more
doaj
Antecedents and outcomes of personnel perceptions of the effectiveness of career management practices in the New Zealand Defence Force : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]
This research examined antecedents and outcomes of perceptions of the effectiveness of career management practices (PECMP) using a military sample. Past research has shown mixed results regarding the relationship between experiencing career management ...
White, Stephanie Nicole
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
This study examines factors influencing organizational citizenship behavior in an organization. These factors include procedural justice, distributive justice, job satisfaction and commitment.
Harif Amali Rifai
doaj +1 more source
The effects of compassion experienced by SME employees on affective commitment: Double-mediation of authenticity and positive emotion [PDF]
The purpose of this study is to empirically examine the effects of compassion experienced by small-to-medium enterprise (SME) employees on affective commitment through authenticity and positive emotion. This study was conducted with 200 employees working
Sung-Hoon Ko, Yongjun Choi
doaj +1 more source

