Results 101 to 110 of about 7,446,825 (333)
Early clinical predictors and correlates of long-term morbidity in bipolar disorder [PDF]
, 2017 OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD).
Baldessarini, R. J. +8 more
core +1 more source
Homocysteine levels in schizophrenia and affective disorders—focus on cognition
Frontiers in Behavioral Neuroscience, 2014 Although homocysteine (Hcy) has been widely implicated in the etiology of various physical health impairments, especially cardiovascular diseases, overwhelming evidence indicates that Hcy is also involved in the pathophysiology of schizophrenia and ...
A. Moustafa +4 more
semanticscholar +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
PSYCHOSIS AND DEPRESSION – A NEUROBIOLOGICAL VIEW [PDF]
, 2009 Psychosis and depression are syndromes that affect the most basic human processes of perception and judgment. Traditional dichotomous classification of psychotic and affective disorders resolved in strict separation between schizophrenia on one hand and ...
Peter Pregelj
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Frontiers in Psychiatry, 2018 Background: The clinical and etiological heterogeneity of mood disorders impede identification of effective treatments for the individual patient. This highlights a need for early neuronal and behavioral biomarkers for treatment efficacy, which can ...
Ida Seeberg +4 more
doaj +1 more source
Left and right amygdala : mediofrontal cortical functional connectivity is differentially modulated by harm avoidance [PDF]
, 2014 Background: The left and right amygdalae are key regions distinctly involved in emotion-regulation processes. Individual differences, such as personality features, may affect the implicated neurocircuits.
Baeken, Chris +6 more
core +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Psychological adaptation to extreme environments: Antarctica as a space analogue [PDF]
, 2018 Space analogues are settings where particular conditions can be reproduced to study physiological and psychological variables experienced in space. Antarctica is one of the most reliable analogues to assess the effects of isolation, confinement, light ...
Barbarito, Marta +5 more
core +1 more source