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Therapy of Affective Disorders

Primary Care: Clinics in Office Practice, 1990
The key to the proper treatment of affective disorder is a correct diagnosis of the subtype of depressive illness. Thus, primary treatment recommendations include the TCAs for a depressive episode; ECT for a depressive episode with psychotic features; and MAOIs for dysthymic disorder and atypical depressive episodes.
B, Alexander, B, Cook
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The Course of Affective Disorders

Psychopathology, 2010
Onset, course, and outcome of affective disorders were studied prospectively – at 5-year intervals, until 1980 – in 406 patients admitted to the Psychiatric University Hospital, Zurich, between 1959 and 1963. A few results are summarized. Bipolar I and bipolar II disorders take a very similar course.
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Magnesium and Affective Disorders

Nutritional Neuroscience, 2002
There are several findings on the action of magnesium ions supporting their possible therapeutic potential in affective disorders. Examinations of the sleep-electroencephalogram (EEG) and of endocrine systems point to the involvement of the limbic-hypothalamus-pituitary-adrenocortical axis as magnesium affects all elements of this system. Magnesium has
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Hypocholesterolemia and Affective Disorders

The American Journal of the Medical Sciences, 1994
The authors' specific aim was to assess hypocholesterolemia in 203 patients hospitalized because of affective disorders (depression, bipolar disorder, and schizoaffective disorder) compared with 1,595 self-referred subjects in an urban supermarket screening and with 11,864 subjects in the National Health and Nutrition Examination Survey II, a national ...
C J, Glueck   +5 more
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Alcoholism and Affective Disorder

Alcoholism: Clinical and Experimental Research, 1985
From January to November 1980, 421 consecutive new patient admissions to a large alcohol treatment facility were interviewed and diagnosed using the Affective Disorder Section of the Research Diagnostic Criteria. The patient population was divided into two groups based on the presence of an affective disorder diagnosis.
A R, Bedi, J A, Halikas
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Seasonality in affective disorders

General and Comparative Endocrinology, 2018
Humans retain neurobiological responses to circadian day-night cycles and seasonal changes in daylength in spite of a life-style usually independent of dawn-dusk signals. Seasonality has been documented in many functions, from mood to hormones to gene expression.
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Neurogenesis and affective disorders

European Journal of Neuroscience, 2011
AbstractThe neurogenesis hypothesis of depression was originally formed upon the demonstration that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work has established that newborn neurons in the dentate gyrus are required for mediating some of the beneficial effects of antidepressant treatment. Recent studies combining
Benjamin A, Samuels, René, Hen
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Indoleamines and affective disorders

Journal of Psychiatric Research, 1972
Abstract The role of the indoleamines in the affective disorders is reviewed. There is increasing evidence of abnormal indoleamine metabolism in depression and mania. In depression the urinary excretion of tryptamine and the cerebrospinal fluid concentration of 5-hydroxy-indoleacetic acid is considerably reduced.
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Biochemistry of the Affective Disorders

Hospital Practice, 1979
Specific brain biochemical anomalies in depression and mania remain to be fully elucidated, but some significant clinical progress has been made. The “norepinephrine hypothesis” has led to approaches that often make it possible to single out the patient most likely to respond to a particular tricyclic agent. In some patients, deranged circadian rhythms
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Alcoholism and affective disorder

American Journal of Psychiatry, 1986
L H, Price, J C, Nelson
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