Results 161 to 170 of about 132,244 (301)

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

INTEGRATING SOCIOMETRIC TECHNIQUES IN ASSESSING THE AFFECTIVE DOMAIN IN HIGHER EDUCATION [PDF]

open access: yes
Studies have shown that educational assessment emphasizes more the cognitive domain of learning. Educational experience has also shown that test instruments are mainly used in the educational system for assessment of learning than the use of non ...
Kunuba, Agatha Chukwufumnanya
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Is the Body an Immanent Domain? On Postsecular Affects

open access: yes452ºF, 2016
¿Qué problemas y posibilidades críticas emergen cuando se juntan la teoría de los afectos y el postsecularismo? Este artículo explora esa pregunta y sus implicaciones en la teoría literaria. ¿Puede el afecto abrir un espacio más allá de la racionalidad mientras se mantiene, al mismo tiempo, enfáticamente materialista y clausura sentimientos religiosos ...
openaire   +3 more sources

DEVELOPING INSTRUMENT TO MEASURE RELIGIOSITY AND OTHER AFFECTIVE DOMAIN IN TEACHING AND LEARNING MATHEMATICS

open access: yes, 2015
Mathematics is a universal knowledge that useful for human life. Competence in mathematics learning is not only focused on the cognitive domain, but also on affective domain.
Jailani, ., Dewi, Mardhiyana
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

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