Results 41 to 50 of about 4,185 (241)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Social Media, Affective Polarization, and Collective Action in Peru

Communication & Society (Formerly Comunicación y Sociedad)
Affective polarization has become a worldwide phenomenon that impacts the ability to engage in meaningful dialogue and reflective consideration of different available courses of action. Social media use has been linked to phenomena such as homophily and
Fernando Ruiz-Dodobara, Karla-A. Uribe-Bravo, Hernán Chaparro   +2 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Conceptualizing Affective Climate Polarization

Socius
Existing research demonstrates that liberals are more likely than conservatives to endorse climate policies. Scholars attribute this to differences in worldviews, elite cues, and misinformation. But political divisions are also emotional, as evidenced by
Emily Huddart, Tony Silva, Parker Muzzerall, Sophia Dimitrakopoulos   +3 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Quantifying Influencer Impact on Affective Polarization

2024 International Conference on Machine Learning and Applications (ICMLA)
8 pages, 4 ...
Rezaur Rashid, Joshua Melton, Ouldouz Ghorbani, Siddharth Krishnan, Shannon Reid, Gabriel Terejanu   +5 more
openaire   +3 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Social Media and Affective Polarization: The mediating Role of Political Sensitivity

Psikoloji Çalışmaları
Affective polarization is defined by intense negative emotions between partisan groups and has seen a rapid increase worldwide, posing risks to democratic institutions and crisis management. This study examines the mediating role of political sensitivity
Lulu Farshana Moolathingal, Namrata
doaj   +1 more source

Ideological and affective polarization in multiparty systems

, 2023
Inspired by increasingly partisan politics in the US, a burgeoning literature on affective polarization applies the concept to multiparty systems. While there are many literature reviews on polarization in the US, as of yet there exists no comparable stocktaking of comparative research on polarization in multiparty systems.
Arndt Leininger, Felix Grünewald, Nelly Buntfuß   +2 more
openaire   +1 more source