Results 41 to 50 of about 3,883 (241)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Social Media, Affective Polarization, and Collective Action in Peru

Communication & Society (Formerly Comunicación y Sociedad)
Affective polarization has become a worldwide phenomenon that impacts the ability to engage in meaningful dialogue and reflective consideration of different available courses of action. Social media use has been linked to phenomena such as homophily and
Fernando Ruiz-Dodobara, Karla-A. Uribe-Bravo, Hernán Chaparro   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Conceptualizing Affective Climate Polarization

Socius
Existing research demonstrates that liberals are more likely than conservatives to endorse climate policies. Scholars attribute this to differences in worldviews, elite cues, and misinformation. But political divisions are also emotional, as evidenced by
Emily Huddart, Tony Silva, Parker Muzzerall, Sophia Dimitrakopoulos   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Quantifying Influencer Impact on Affective Polarization

2024 International Conference on Machine Learning and Applications (ICMLA)
8 pages, 4 ...
Rezaur Rashid, Joshua Melton, Ouldouz Ghorbani, Siddharth Krishnan, Shannon Reid, Gabriel Terejanu   +5 more
openaire   +3 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Social Media as an Alter Ego of Reality: What Does Affective Political Polarization Teach Us?

RUDN Journal of Political Science
Affective political polarization is comprehensively considered in combination of its emotional, behavioral and cognitive aspects. They manifest themselves in the differences between an individual’s attitude towards politically like-minded people (the in ...
Denis K. Stukal, Anna N. Shilina, Andrei S. Akhremenko   +2 more
doaj   +1 more source

Ideological and affective polarization in multiparty systems

, 2023
Inspired by increasingly partisan politics in the US, a burgeoning literature on affective polarization applies the concept to multiparty systems. While there are many literature reviews on polarization in the US, as of yet there exists no comparable stocktaking of comparative research on polarization in multiparty systems.
Arndt Leininger, Felix Grünewald, Nelly Buntfuß   +2 more
openaire   +1 more source