Results 51 to 60 of about 3,883 (241)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Methodology for Measuring Individual Affective Polarization Using Sentiment Analysis in Social Networks

IEEE Access
Affective polarization has important consequences for societies and institutions. At the institutional level, it hinders agreement among political actors, which damages the stability of the system. At the social level, it increases tensions and conflicts
Raquel Martinez-Espana, Julio Fernandez-Pedauye, Jose Giner-Perez de Lucia, Jose Miguel Rojo-Martinez, Kaoutar Bakdid-Albane, Juan Jose Garcia-Escribano   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Learning to Recognize Affective Polarity in Similes [PDF]

Proceedings of the 2015 Conference on Empirical Methods in Natural Language Processing, 2015
A simile is a comparison between two essentially unlike things, such as “Jane swims like a dolphin”. Similes often express a positive or negative sentiment toward something, but recognizing the polarity of a simile can depend heavily on world knowledge. For example, “memory like an elephant” is positive, but “memory like a sieve” is negative.
Qadir, Ashequl, Riloff, Ellen, Walker, Marilyn   +2 more
openaire   +3 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Voting Advice Applications and Their Impact on Ideological and Affective Polarization

Politics and Governance
Political polarization has been one of the most researched topics in political science over the past few years. While many scholars focus on the factors that foster ideological and affective polarization, less is known about the drivers of depolarization.
Maxime Walder, Jan Fivaz, Daniel Schwarz
doaj   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Affective Polarization in the Russian Social Media Within the Political Mobilization: A Machine Learning Approach

RUDN Journal of Political Science
In the context of the current rise in global political tensions and widespread protests, the examination of affective polarization dynamics has become increasingly significant.
Ekaterina V. Kruchinskaia
doaj   +1 more source

Partisan Affective Polarization

Public Opinion Quarterly, 2020
Abstract Partisan affective polarization, measured with feeling thermometer ratings, has increased gradually in the United States over a long period. This article describes how affective polarization and its composite parts, rival-party and own-party feelings, have changed over time.
openaire   +1 more source