Results 51 to 60 of about 4,185 (241)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Social Media as an Alter Ego of Reality: What Does Affective Political Polarization Teach Us?

RUDN Journal of Political Science
Affective political polarization is comprehensively considered in combination of its emotional, behavioral and cognitive aspects. They manifest themselves in the differences between an individual’s attitude towards politically like-minded people (the in ...
Denis K. Stukal, Anna N. Shilina, Andrei S. Akhremenko   +2 more
doaj   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Conceptual Foundations of Affective Polarization: Two Notions of Affect

European Journal of Analytic Philosophy
In this paper we argue that the literature on affective states has converged onto two interrelated, but ultimately distinct (and non-derivative) notions of affect: one that characterizes affective states as those with a certain functional profile, and ...
Aarón Álvarez-González, Aida Roige
doaj   +1 more source

Learning to Recognize Affective Polarity in Similes [PDF]

Proceedings of the 2015 Conference on Empirical Methods in Natural Language Processing, 2015
A simile is a comparison between two essentially unlike things, such as “Jane swims like a dolphin”. Similes often express a positive or negative sentiment toward something, but recognizing the polarity of a simile can depend heavily on world knowledge. For example, “memory like an elephant” is positive, but “memory like a sieve” is negative.
Qadir, Ashequl, Riloff, Ellen, Walker, Marilyn   +2 more
openaire   +3 more sources

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Methodology for Measuring Individual Affective Polarization Using Sentiment Analysis in Social Networks

IEEE Access
Affective polarization has important consequences for societies and institutions. At the institutional level, it hinders agreement among political actors, which damages the stability of the system. At the social level, it increases tensions and conflicts
Raquel Martinez-Espana, Julio Fernandez-Pedauye, Jose Giner-Perez de Lucia, Jose Miguel Rojo-Martinez, Kaoutar Bakdid-Albane, Juan Jose Garcia-Escribano   +5 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Performative Contingency and Affective Polarization

European Journal of Analytic Philosophy
Recent philosophical approaches to affective polarization have moved beyond purely identitarian and emotivist frameworks, emphasizing instead its multi-dimensional structure.
Patrizia Pedrini, Jacopo Marchetti
doaj   +1 more source