Dopaminergic modulation of the voltage-gated sodium current in the cochlear afferent neurons of the rat. [PDF]
PLoS ONE, 2015 The cochlear inner hair cells synapse onto type I afferent terminal dendrites, constituting the main afferent pathway for auditory information flow. This pathway receives central control input from the lateral olivocochlear efferent neurons that release ...
Catalina Valdés-Baizabal +2 more
doaj +1 more source
In search of afferent pathways of a cardiogenic hypertensive chemoreflex. [PDF]
Circulation, 1987 Injection of serotonin (5-HT) into the left atrium or ventricle activates a hypertensive chemoreflex. The primary purpose of our study was to determine the afferent pathway(s) that mediates this response. A secondary goal was to localize the receptive sites of this reflex.
U J Johannsen, M D Thames, Allyn L. Mark
openaire +3 more sources
On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]
, 2013 The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F +6 more
core +3 more sources
Post‐Processing Strengthened 3D Artificial Fingertip with Multi‐Intensity Pain Perception
Advanced Materials Technologies, EarlyView.The 3D multi‐intensity pain‐perceptive artificial fingertip (HBAF) is designed, whose mechanical and conductive properties are highly improved via novel post‐processing. With the soft adhesive gel layer, which is grown on the base of HBAF, it is seamlessly assembled with the robotic hand and further evaluates the safe factor of gripping.
Huijing Li +6 more
wiley +1 more source
Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control
Frontiers in Physiology, 2017 Oxygen sensing mechanisms are vital for homeostasis and survival. When oxygen levels are too low (hypoxia), blood flow has to be increased, metabolism reduced, or a combination of both, to counteract tissue damage.
Daniela Patinha +5 more
doaj +1 more source
Stepping Responses to Treadmill Perturbations vary with Severity of Motor Deficits in Human SCI [PDF]
, 2018 In this study, we investigated the responses to tread perturbations during human stepping on a treadmill. Our approach was to test the effects of perturbations to a single leg using a split-belt treadmill in healthy participants and in participants with ...
Chu, Virginia W. T. +2 more
core +2 more sources
LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
Frontiers in Neuroscience, 2018 Background and Objectives: Bidirectional signaling between the gastrointestinal tract and the brain is vital for maintaining whole-body homeostasis. Moreover, emerging evidence implicates vagal afferent signaling in the modulation of host physiology by ...
Maria M. Buckley +3 more
doaj +1 more source
Central and peripheral contributions of T-type calcium channels in pain
Molecular Brain, 2022 Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among the key players in this pathway are T-type calcium channels, in particular the Cav3.2 isoform. Because of
Erika K. Harding, Gerald W. Zamponi
doaj +1 more source
Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]
, 2008 The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G. +3 more
core +4 more sources