Results 71 to 80 of about 68,911 (310)

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Pathologic fracture of mandibular ramus in a patient with familial dysautonomia: A case report

Oral and Maxillofacial Surgery Cases
Familial dysautonomia is a rare disease that impairs the development of sensory nerves, afferent autonomic nerves, and afferent baroreflex pathways.
Patrick J. Nolan, David Koslovsky, Drew Roberts   +2 more
doaj   +1 more source

Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor

, 2005
SummaryA major unanswered question concerning “pain” circuitry is the extent to which different populations of primary afferent nociceptor engage the same or different ascending pathways. In the present study, we followed the transneuronal transport of a
Braz, Joao M., Nassar, Mohammed A., Wood, John N., Basbaum, Allan I.   +3 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Patterns of cytokine gene expression of naïve and memory T lymphocytes in vivo.

, 2002
Large-scale lymphocyte recirculation occurs only at the level of secondary lymphoid tissue. Cells enter lymph nodes via afferent lymph from the tissue and via arterioles from the blood. They exit only via the efferent duct.
Hopkins, John, Hunter, Nora, Bailey, S., Gossner, Anton   +3 more
core  

In search of afferent pathways of a cardiogenic hypertensive chemoreflex.

, 1987
Injection of serotonin (5-HT) into the left atrium or ventricle activates a hypertensive chemoreflex. The primary purpose of our study was to determine the afferent pathway(s) that mediates this response.
M D Thames, U J Johannsen, A L Mark
core   +1 more source

Age-related changes in afferent pathways and urothelial function in the male mouse bladder [PDF]

, 2014
The prevalence of lower urinary tract storage disorders such as overactive bladder syndrome and urinary incontinence significantly increase with age. Previous studies have demonstrated age-related changes in detrusor function and urothelial transmitter ...
McKay, Neil G., David Grundy, Donna M. Daly, Nocchi, L., Grundy, D., Linda Nocchi, Marina Liaskos, Neil G. McKay, Grundy, David, Daly, Donna M., Daly, D.M., Liaskos, M., McKay, N.G., Liaskos, Marina, Chapple, Christopher, Mckay, Neil, Nocchi, Linda, Daly, Donna, Christopher Chapple, Chapple, C.   +19 more
core   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Gut-to-brain interoceptive pathways in emotion-related behaviors

Frontiers in Systems Neuroscience
Emotion-related states encompass a wide range of affective and behavioral dimensions, including anxiety, fear, pleasure, and aversion, whereas motivation refers to internal drives that energize goal-directed behaviors such as feeding, reward seeking, or ...
Tomofumi Otsuki, Takako Ichiki, Miho Terunuma   +2 more
doaj   +1 more source