Results 51 to 60 of about 68,911 (310)
Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus
Molecules, 2021 Heartburn and non-cardiac chest pain are the predominant symptoms in many esophageal disorders, such as gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), functional heartburn and chest pain, and eosinophilic esophagitis (EoE). At
Mingwei Yu +3 more
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Advanced Science, EarlyView.FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong +10 more
wiley +1 more source
Frontiers in Neuroscience, 2018 Background and Objectives: Bidirectional signaling between the gastrointestinal tract and the brain is vital for maintaining whole-body homeostasis. Moreover, emerging evidence implicates vagal afferent signaling in the modulation of host physiology by ...
Maria M. Buckley +3 more
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Dopaminergic modulation of the voltage-gated sodium current in the cochlear afferent neurons of the rat. [PDF]
PLoS ONE, 2015 The cochlear inner hair cells synapse onto type I afferent terminal dendrites, constituting the main afferent pathway for auditory information flow. This pathway receives central control input from the lateral olivocochlear efferent neurons that release ...
Catalina Valdés-Baizabal +2 more
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Afferent diversity and the organization of central vestibular pathways [PDF]
Experimental Brain Research, 2000 This review considers whether the vestibular system includes separate populations of sensory axons innervating individual organs and giving rise to distinct central pathways. There is a variability in the discharge properties of afferents supplying each organ.
openaire +2 more sources
Advanced Science, EarlyView.This work proposed a pollen‐enhanced bionic mechanoreceptor based on ionic convection. Leveraging the ion anchoring effect of the pollen particle, the output performance could be ∼12 times higher than the original state. By employing deep learning models as AI brains, the feasibility of a sensory‐augmented prosthesis consisting of a pollen‐enhanced ...
Zi Hao Guo +7 more
wiley +1 more source
Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control
Frontiers in Physiology, 2017 Oxygen sensing mechanisms are vital for homeostasis and survival. When oxygen levels are too low (hypoxia), blood flow has to be increased, metabolism reduced, or a combination of both, to counteract tissue damage.
Daniela Patinha +5 more
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Convergence in a thermal afferent pathway in the rat. [PDF]
The Journal of Physiology, 1975 1. In anaesthetized rats, unit activity was recorded in the afferent somatosensory pathway leading from the scrotum. Recording sites were in the dorsal horn near the entry zone of the scrotal nerve, in the ventrobasal complex of the thalamus and in the somatosensory (SI) cortex.
R F, Hellon, D, Mitchell
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, 2016 Background: Magnocellular neurosecretory neurons of the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei synthesize vasopressin and oxytocin in response to signals generated by osmoreceptors and baroreceptors and, respectively, by receptors
GUASTAMACCHIA, Edoardo +11 more
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Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain
Advanced Science, EarlyView.In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun +27 more
wiley +1 more source