Results 71 to 80 of about 2,661,024 (373)

Development of an ex Vivo Method for Multi-unit Recording of Microbiota-Colonic-Neural Signaling in Real Time

Frontiers in Neuroscience, 2018
Background and Objectives: Bidirectional signaling between the gastrointestinal tract and the brain is vital for maintaining whole-body homeostasis. Moreover, emerging evidence implicates vagal afferent signaling in the modulation of host physiology by ...
Maria M. Buckley, Maria M. Buckley, Dervla O'Malley, Dervla O'Malley   +3 more
doaj   +1 more source

Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury [PDF]

, 2018
Many studies highlight the remarkable plasticity demonstrated by spinal circuits following an incomplete spinal cord injury (SCI). Such plasticity can contribute to improvements in volitional motor recovery, such as walking function, although similar ...
Hornby, T. George, Kim, Hyosub E., Leech, Kristan A.   +2 more
core   +2 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Cooperative Oxygen Sensing by the Kidney and Carotid Body in Blood Pressure Control

Frontiers in Physiology, 2017
Oxygen sensing mechanisms are vital for homeostasis and survival. When oxygen levels are too low (hypoxia), blood flow has to be increased, metabolism reduced, or a combination of both, to counteract tissue damage.
Daniela Patinha, Daniela Patinha, Wioletta Pijacka, Julian F. R. Paton, Maarten P. Koeners, Maarten P. Koeners   +5 more
doaj   +1 more source

Central and peripheral contributions of T-type calcium channels in pain

Molecular Brain, 2022
Chronic pain is a severely debilitating condition that reflects a long-term sensitization of signal transduction in the afferent pain pathway. Among the key players in this pathway are T-type calcium channels, in particular the Cav3.2 isoform. Because of
Erika K. Harding, Gerald W. Zamponi
doaj   +1 more source

Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion-extension movements [PDF]

, 2008
The present research investigates factors contributing to bradykinesia in the control of simple and complex voluntary limb movement in Parkinson’s disease (PD) patients.
Geelen, J.A.G., Heida, Tjitske, Moroney, Rachel, Rinzel, J.   +3 more
core   +4 more sources

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Central neuromechanisms underlying control of intragastric pressure through acupuncture at Zusanli (ST36) in rats: the upper cervical cord is the key link between the ascending and descending pathways

Neural Regeneration Research, 2016
Sensory inputs stimulated by Zusanli (ST36) acupuncture in the abdomen are known to converge in the upper cervical cord. However, it is unclear whether these inputs are subsequently conveyed to the hypothalamic paraventricular nucleus and what kind of ...
Chun-yan Yong, Shu Chen, Heng Chen, Xiao Chu, Chao Zhang, Cheng Tan, Lan Ye, Jiang-shan Li   +7 more
doaj   +1 more source

Circadian variation in gastric vagal afferent mechanosensitivity [PDF]

, 2013
Food intake is coordinated to cellular metabolism by clock gene expression with a master clock in the suprachiasmatic nucleus synchronized by light exposure.
Frisby, C.L., Kennaway, D., Kentish, S., Page, A., Wittert, G.   +4 more
core   +2 more sources

Exercise intolerance and fatigue in chronic heart failure: is there a role for group III/IV afferent feedback? [PDF]

, 2020
Exercise intolerance and early fatiguability are hallmark symptoms of chronic heart failure. While the malfunction of the heart is certainly the leading cause of chronic heart failure, the patho-physiological mechanisms of exercise intolerance in these ...
Angius, Luca, Crisafulli, Antonio
core   +2 more sources