Results 31 to 40 of about 1,718 (258)

The Erlangen Program in lateral occipital cortex: Hierarchical encoding of emergent features

open access: yesNeuroImage
Emergent features are fundamental concepts in Gestalt psychology, yet the neural encoding of these features, particularly a quantitative understanding of their relative superiority, remains elusive. This study bridges this gap by conceptualizing emergent
Junjun Zhang   +5 more
doaj   +1 more source

Aerodynamic Shape Optimization with Grassmannian Shape Parameterization Method

open access: yesEnergies, 2022
The conventional method of optimizing the aerodynamic performance of an airfoil heavily depends on the confines of the design space. The design variables create a non-normalized space that is fragmented into several different clusters of airfoils.
Yang Zhang   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A Unified Approach to Aitchison’s, Dually Affine, and Transport Geometries of the Probability Simplex

open access: yesAxioms
A critical processing step for AI algorithms is mapping the raw data to a landscape where the similarity of two data points is conveniently defined. Frequently, when the data points are compositions of probability functions, the similarity is reduced to ...
Giovanni Pistone, Muhammad Shoaib
doaj   +1 more source

On The Investigating Cycle Properties In The Galilean Plane G^2

open access: yesEurasian Journal of Science and Engineering, 2023
The introduction of the Galilean plane within the affine plane parallels the familiar concepts of the Euclidean plane, extending the realm of geometric exploration.
Abdullah Kurudirek
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Comparing equivalent gravities: common features and differences

open access: yesEuropean Physical Journal C: Particles and Fields, 2022
We discuss equivalent representations of gravity in the framework of metric-affine geometries pointing out basic concepts from where these theories stem out.
Salvatore Capozziello   +2 more
doaj   +1 more source

Stewart’s Theorem and Median Property in the Galilean Plane

open access: yesJournal of Advanced Research in Natural and Applied Sciences, 2023
Galilean plane can be introduced in the affine plane, as in Euclidean plane. This means that the concepts of lines, parallel lines, ratios of collinear segments, and areas of figures are significant not only in Euclidean plane but also in Galilean plane.
Abdulaziz Açıkgöz, Nilgün Sönmez
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Block-Graceful Designs

open access: yesJournal of Mathematics, 2023
In this article, we adapt the edge-graceful graph labeling definition into block designs and define a block design V,B with V=v and B=b as block-graceful if there exists a bijection f:B⟶1,2,…,b such that the induced mapping f+:V⟶Zv given by f+x=∑x∈AA ...
Dilara Erdemir, Emre Kolotoğlu
doaj   +1 more source

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